Phosphodiesterase 4 Inhibitor drugs compared
Compare all 5 Phosphodiesterase 4 Inhibitor drugs side by side, used for conditions such as arthritis, psoriatic, pulmonary disease, chronic obstructive, dermatitis, atopic. They share one FDA-defined mechanism but differ in approved uses, prescription status, brand-vs-generic options, price, and FDA recall-safety record — which our independent rating scores. The highest-rated is otezla.
Top-rated phosphodiesterase 4 inhibitor: 1. Otezla · 2. Otezla XR · 3. Daliresp
| Drug | Generic | Form | Status | Used for | Safety ratingFDA recall-based | Pharmacy pays |
|---|---|---|---|---|---|---|
| Otezla | Apremilast | Tablet | Prescription | Arthritis, Psoriatic | 72/100 | — |
| Otezla XR | Apremilast | Tablet | Prescription | Arthritis, Psoriatic | 72/100 | — |
| Daliresp | Roflumilast | Tablet | Prescription | Pulmonary Disease, Chronic Obstructive | 70/100 | $10 |
| Eucrisa | Crisaborole | Topical | Prescription | Dermatitis, Atopic | Not yet rated | — |
| Zoryve | Roflumilast | Topical | Prescription | Pulmonary Disease, Chronic Obstructive | Not yet rated | $10 |
The safety rating column is unique to pharmaranks — an independent 0–100 score from FDA regulatory recall data. Higher is safer. Not medical advice.
Best phosphodiesterase 4 inhibitor by condition
Full ranking · 5 drugs
- 172/100
otezla
Apremilast
- 272/100
otezla xr
Apremilast
- 370/100
daliresp
Roflumilast
- 4New
eucrisa
Crisaborole
- 5New
zoryve
Roflumilast
Frequently asked questions
What is the Phosphodiesterase 4 Inhibitor drug class?
Phosphodiesterase 4 Inhibitor is an FDA Established Pharmacologic Class (EPC) — a group of drugs that share a mechanism of action. pharmaranks lists 5 Phosphodiesterase 4 Inhibitor products, each independently rated.
Are all Phosphodiesterase 4 Inhibitor drugs the same?
No. Phosphodiesterase 4 Inhibitor drugs share the same core mechanism — that is why they sit in one FDA class — but they differ in their approved uses, available forms, whether they are prescription or over-the-counter, brand-vs-generic options and price, and their FDA recall-safety record.
What conditions do Phosphodiesterase 4 Inhibitor drugs treat?
Per NIH RxClass drug-classification data, Phosphodiesterase 4 Inhibitor drugs are used for conditions including arthritis, psoriatic, pulmonary disease, chronic obstructive, dermatitis, atopic.
Which Phosphodiesterase 4 Inhibitor drug is best-rated?
By our independent rating, otezla currently ranks highest among Phosphodiesterase 4 Inhibitor drugs. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.
Sources: the Phosphodiesterase 4 Inhibitor class definition and its member drugs come from the U.S. NLM RxClass (Established Pharmacologic Class). Ratings are pharmaranks’ independent FDA recall-safety analysis.