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Guanylate Cyclase-C Agonist drugs compared

Compare all 1 Guanylate Cyclase-C Agonist drug side by side, used for conditions such as constipation, irritable bowel syndrome. They share one FDA-defined mechanism but differ in approved uses, prescription status, brand-vs-generic options, price, and FDA recall-safety record — which our independent rating scores.

1 of 1 drug in this class carry a pharmaranks safety score, ranging 70–70 out of 100 — computed from FDA recall records, not from reviews.

Rated against independent sources·Last updated June 7, 2026·How we rate

Full ranking · 1 drugs

  1. 1

    linzess

    Linaclotide

    70/100

Frequently asked questions

What is the Guanylate Cyclase-C Agonist drug class?

Guanylate Cyclase-C Agonist is an FDA Established Pharmacologic Class (EPC) — a group of drugs that share a mechanism of action. pharmaranks lists 1 Guanylate Cyclase-C Agonist product, each independently rated.

Are all Guanylate Cyclase-C Agonist drugs the same?

No. Guanylate Cyclase-C Agonist drugs share the same core mechanism — that is why they sit in one FDA class — but they differ in their approved uses, available forms, whether they are prescription or over-the-counter, brand-vs-generic options and price, and their FDA recall-safety record.

What conditions do Guanylate Cyclase-C Agonist drugs treat?

Per NIH RxClass drug-classification data, Guanylate Cyclase-C Agonist drugs are used for conditions including constipation, irritable bowel syndrome.

Sources: the Guanylate Cyclase-C Agonist class definition and its member drugs come from the U.S. NLM RxClass (Established Pharmacologic Class). Ratings are pharmaranks’ independent FDA recall-safety analysis.