Antimalarial drugs compared
Compare all 5 Antimalarial drugs side by side, used for conditions such as amebiasis, arthritis, rheumatoid, lupus erythematosus, discoid. They share one FDA-defined mechanism but differ in approved uses, prescription status, brand-vs-generic options, price, and FDA recall-safety record — which our independent rating scores. The highest-rated is chloroquine phosphate.
Top-rated antimalarial: 1. Chloroquine Phosphate · 2. Mepron · 3. Sovuna
| Drug | Generic | Form | Status | Used for | Safety ratingFDA recall-based | Pharmacy pays |
|---|---|---|---|---|---|---|
| Chloroquine Phosphate | — | Tablet | Prescription | Amebiasis, Arthritis, Rheumatoid | 70/100 | — |
| Mepron | Atovaquone | Suspension | Prescription | Pneumonia, Pneumocystis, Toxoplasmosis, Cerebral | 70/100 | $1 |
| Sovuna | Hydroxychloroquine Sulfate | Tablet | Prescription | Arthritis, Rheumatoid, Lupus Erythematosus, Systemic | 70/100 | $5 |
| Hydroxychloroquine Sulfate | — | Tablet | Prescription | Arthritis, Rheumatoid, Lupus Erythematosus, Systemic | Not yet rated | $5 |
| Plaquenil | Hydroxychloroquine Sulfate | Tablet | Prescription | Arthritis, Rheumatoid, Lupus Erythematosus, Systemic | Not yet rated | $5 |
The safety rating column is unique to pharmaranks — an independent 0–100 score from FDA regulatory recall data. Higher is safer. Not medical advice.
Best antimalarial by condition
Full ranking · 5 drugs
- 170/100
chloroquine phosphate
Chloroquine Phosphate
- 270/100
mepron
Atovaquone
- 370/100
sovuna
Hydroxychloroquine Sulfate
- 4New
hydroxychloroquine sulfate
Hydroxychloroquine Sulfate
- 5New
plaquenil
Hydroxychloroquine Sulfate
Frequently asked questions
What is the Antimalarial drug class?
Antimalarial is an FDA Established Pharmacologic Class (EPC) — a group of drugs that share a mechanism of action. pharmaranks lists 5 Antimalarial products, each independently rated.
Are all Antimalarial drugs the same?
No. Antimalarial drugs share the same core mechanism — that is why they sit in one FDA class — but they differ in their approved uses, available forms, whether they are prescription or over-the-counter, brand-vs-generic options and price, and their FDA recall-safety record.
What conditions do Antimalarial drugs treat?
Per NIH RxClass drug-classification data, Antimalarial drugs are used for conditions including amebiasis, arthritis, rheumatoid, lupus erythematosus, discoid, malaria, avian, pemphigus, scleroderma, systemic.
Which Antimalarial drug is best-rated?
By our independent rating, chloroquine phosphate currently ranks highest among Antimalarial drugs. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.
Sources: the Antimalarial class definition and its member drugs come from the U.S. NLM RxClass (Established Pharmacologic Class). Ratings are pharmaranks’ independent FDA recall-safety analysis.