Can you take triprolidine while breastfeeding?
What LactMed says
The National Library of Medicine’s own summary, quoted in full. We do not write a verdict of our own on this question, and we do not compress theirs into a label.
Small, occasional doses of triprolidine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.
Quoted from Triprolidine — Drugs and Lactation Database (LactMed®), National Institute of Child Health and Human Development, revised September 15, 2025.
How much triprolidine gets into breastmilk
Maternal Levels. Single doses of triprolidine of 2.5 mg produced peak milk levels of about 7 to 9 mcg/L at about 1 to 2 hours after the dose in 3 women. Milk levels fell with half-lives ranging from 2.8 to 18.9 hours among the 3 mothers. The dose a fully breastfed infant would receive was calculated to be 0.6 to 0.2% of the mother's weight-adjusted dosage.
Infant Levels. Relevant published information was not found as of the revision date.
What has been seen in breastfed infants
In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the mothers were taking triprolidine.
In one study, no infant side effects were reported in three infants whose mothers took one dose of triprolidine 2.5 mg and pseudoephedrine 60 mg.
Effects on milk supply
Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women. However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers. Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Frequently asked questions
Can you take triprolidine while breastfeeding?
Small, occasional doses of triprolidine would not be expected to cause any adverse effects in breastfed infants. The full record is quoted on this page, and the decision is one to make with the person who prescribed it — LactMed itself states it is not a substitute for professional judgement.
Does triprolidine pass into breastmilk?
LactMed's measured drug levels for triprolidine are quoted in full on this page, under "How much gets into breastmilk".
Do I need to pump and dump after taking triprolidine?
LactMed does not frame its records that way — it reports measured drug levels in milk and what has been observed in breastfed infants, which is what this page quotes. "Pump and dump" advice for a specific drug and dose should come from your clinician or a pharmacist, not from a general rule.
More on triprolidine
LactMed states that the information it presents is not a substitute for professional judgement, and that you should consult your healthcare provider for breastfeeding advice related to your particular situation. Nothing on this page is medical advice.