Can you take temsirolimus while breastfeeding?
What LactMed says
The National Library of Medicine’s own summary, quoted in full. We do not write a verdict of our own on this question, and we do not compress theirs into a label.
Temsirolimus is a prodrug of sirolimus. Because no information is available on the use of temsirolimus or sirolimus during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. The manufacturer recommends that breastfeeding be discontinued during temsirolimus therapy and for 3 weeks following the last dose.
Quoted from Temsirolimus — Drugs and Lactation Database (LactMed®), National Institute of Child Health and Human Development, revised October 23, 2019.
What LactMed would consider instead
LactMed ends this record by naming the drugs it would consider in place of temsirolimus. Whether any of them fits depends on what you are treating — this is the database’s list, not a recommendation from us.
How much temsirolimus gets into breastmilk
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
What has been seen in breastfed infants
Relevant published information was not found as of the revision date.
Effects on milk supply
Relevant published information was not found as of the revision date.
Frequently asked questions
Can you take temsirolimus while breastfeeding?
Temsirolimus is a prodrug of sirolimus. The full record is quoted on this page, and the decision is one to make with the person who prescribed it — LactMed itself states it is not a substitute for professional judgement.
What can I take instead of temsirolimus while breastfeeding?
LactMed lists Azathioprine, Cyclosporine, Tacrolimus as alternate drugs to consider. That is the database's own list for this drug — whether any of them suits you depends on what you are treating.
Does temsirolimus pass into breastmilk?
LactMed's measured drug levels for temsirolimus are quoted in full on this page, under "How much gets into breastmilk".
Do I need to pump and dump after taking temsirolimus?
LactMed does not frame its records that way — it reports measured drug levels in milk and what has been observed in breastfed infants, which is what this page quotes. "Pump and dump" advice for a specific drug and dose should come from your clinician or a pharmacist, not from a general rule.
More on temsirolimus
LactMed states that the information it presents is not a substitute for professional judgement, and that you should consult your healthcare provider for breastfeeding advice related to your particular situation. Nothing on this page is medical advice.