Can you take plecanatide while breastfeeding?
What LactMed says
The National Library of Medicine’s own summary, quoted in full. We do not write a verdict of our own on this question, and we do not compress theirs into a label.
Plecanatide is not absorbed from the gastrointestinal tract and the drug and its active metabolite are not measurable in milk following administration of recommended doses to nursing mothers. Plecanatide is not expected to cause any adverse effects in breastfed infants. No special precautions are required.
Quoted from Plecanatide — Drugs and Lactation Database (LactMed®), National Institute of Child Health and Human Development, revised February 15, 2025.
What LactMed would consider instead
LactMed ends this record by naming the drugs it would consider in place of plecanatide. Whether any of them fits depends on what you are treating — this is the database’s list, not a recommendation from us.
How much plecanatide gets into breastmilk
Maternal Levels. Plecanatide 3 mg was administered orally once daily for 2 weeks to 7 mothers who had been nursing for at least 4 weeks. Plecanatide and its active metabolite were not measurable (detection limit not specified) in breastmilk samples collected before a dose or at 2, 6, or 12 hours after a dose.
Infant Levels. Relevant published information was not found as of the revision date.
What has been seen in breastfed infants
Relevant published information was not found as of the revision date.
Effects on milk supply
Relevant published information was not found as of the revision date.
Frequently asked questions
Can you take plecanatide while breastfeeding?
What the NIH's Drugs and Lactation Database says about Plecanatide while breastfeeding — quoted in full. The full record is quoted on this page, and the decision is one to make with the person who prescribed it — LactMed itself states it is not a substitute for professional judgement.
What can I take instead of plecanatide while breastfeeding?
LactMed lists Linaclotide, Lubiprostone, Prucalopride, Psyllium, Tenapanor as alternate drugs to consider. That is the database's own list for this drug — whether any of them suits you depends on what you are treating.
Does plecanatide pass into breastmilk?
LactMed's measured drug levels for plecanatide are quoted in full on this page, under "How much gets into breastmilk".
Do I need to pump and dump after taking plecanatide?
LactMed does not frame its records that way — it reports measured drug levels in milk and what has been observed in breastfed infants, which is what this page quotes. "Pump and dump" advice for a specific drug and dose should come from your clinician or a pharmacist, not from a general rule.
More on plecanatide
LactMed states that the information it presents is not a substitute for professional judgement, and that you should consult your healthcare provider for breastfeeding advice related to your particular situation. Nothing on this page is medical advice.