Can you take laronidase while breastfeeding?
What LactMed says
The National Library of Medicine’s own summary, quoted in full. We do not write a verdict of our own on this question, and we do not compress theirs into a label.
Limited information from on mother receiving laronidase for mucopolysaccharidosis type I indicates that the drug is not detectable in breastmilk and her breastfed infant suffered no adverse reactions or adverse developmental effects from the drug in milk. The lack of penetration into milk is consistent with its high molecular weight of 82,000 Da. If laronidase is required by the mother, it is not a reason to discontinue breastfeeding. Until more data are available, laronidase should be used with careful monitoring during breastfeeding.
Quoted from Laronidase — Drugs and Lactation Database (LactMed®), National Institute of Child Health and Human Development, revised August 15, 2024.
How much laronidase gets into breastmilk
Maternal Levels. A woman with mucopolysaccharidosis type I received intravenous laronidase 100 units/kg weekly during breastfeeding, beginning one week after delivery. Laronidase was undetectable (assay limits not specified) in breastmilk just before the infusion and 60 minutes after the infusion at 1 and 3 months postpartum.
Infant Levels. Relevant published information was not found as of the revision date.
What has been seen in breastfed infants
A woman with mucopolysaccharidosis type I received intravenous laronidase 100 units/kg weekly for 28 doses during her 37-week pregnancy. She resumed therapy one week after delivery and breastfed her infant for 3 months. The infant had normal height and weight up to 12 months of age and showed normal development at 2.5 years of age. No adverse drug reactions were reported in the infant.
Effects on milk supply
Relevant published information was not found as of the revision date.
Frequently asked questions
Can you take laronidase while breastfeeding?
What the NIH's Drugs and Lactation Database says about Laronidase while breastfeeding — quoted in full. The full record is quoted on this page, and the decision is one to make with the person who prescribed it — LactMed itself states it is not a substitute for professional judgement.
Does laronidase pass into breastmilk?
LactMed's measured drug levels for laronidase are quoted in full on this page, under "How much gets into breastmilk".
Do I need to pump and dump after taking laronidase?
LactMed does not frame its records that way — it reports measured drug levels in milk and what has been observed in breastfed infants, which is what this page quotes. "Pump and dump" advice for a specific drug and dose should come from your clinician or a pharmacist, not from a general rule.
More on laronidase
LactMed states that the information it presents is not a substitute for professional judgement, and that you should consult your healthcare provider for breastfeeding advice related to your particular situation. Nothing on this page is medical advice.