Can you take glipizide while breastfeeding?
What LactMed says
The National Library of Medicine’s own summary, quoted in full. We do not write a verdict of our own on this question, and we do not compress theirs into a label.
Limited data indicate that the levels of glipizide in milk are low. However, an alternate drug for which there is more information may be preferred, especially while nursing a newborn or preterm infant. Monitor breastfed infants for signs of hypoglycemia such as jitteriness, excessive sleepiness, poor feeding, seizures cyanosis, apnea, or hypothermia. If there is concern, monitoring of the breastfed infant's blood glucose is advisable during maternal therapy with hypoglycemic agents.
Quoted from Glipizide — Drugs and Lactation Database (LactMed®), National Institute of Child Health and Human Development, revised May 15, 2026.
How much glipizide gets into breastmilk
Two women who had delivered via cesarean section and were receiving glipizide 5 mg daily in the immediate postoperative period had milk glipizide levels measured. Trough glipizide milk levels were undetectable (<80 mcg/L). The authors estimated that the maximum dosages that a fully breastfed infant would receive is <27% of the weight-adjusted maternal dosage.
What has been seen in breastfed infants
Blood glucose levels were normal in 2 breastfed infants whose mothers were taking oral glipizide 5 mg daily.
Effects on milk supply
Relevant published information was not found as of the revision date.
Frequently asked questions
Can you take glipizide while breastfeeding?
Limited data indicate that the levels of glipizide in milk are low. The full record is quoted on this page, and the decision is one to make with the person who prescribed it — LactMed itself states it is not a substitute for professional judgement.
Does glipizide pass into breastmilk?
LactMed's measured drug levels for glipizide are quoted in full on this page, under "How much gets into breastmilk".
Do I need to pump and dump after taking glipizide?
LactMed does not frame its records that way — it reports measured drug levels in milk and what has been observed in breastfed infants, which is what this page quotes. "Pump and dump" advice for a specific drug and dose should come from your clinician or a pharmacist, not from a general rule.
More on glipizide
LactMed states that the information it presents is not a substitute for professional judgement, and that you should consult your healthcare provider for breastfeeding advice related to your particular situation. Nothing on this page is medical advice.