Can you take daclatasvir while breastfeeding?
What LactMed says
The National Library of Medicine’s own summary, quoted in full. We do not write a verdict of our own on this question, and we do not compress theirs into a label.
Daclatasvir is no longer marketed in the United States. It has not been studied in nursing mothers being treated for hepatitis C infection. Because it is 99% bound to maternal plasma proteins, amounts in breastmilk are likely to be very low. If daclatasvir used alone or in combination with sofosbuvir is required by the mother, it is not a reason to discontinue breastfeeding.
Hepatitis C is not transmitted through breastmilk and breastmilk has been shown to inactivate hepatitis C virus (HCV).[2–5] However, the Centers for Disease Control recommends that mothers with HCV infection should consider abstaining from breastfeeding if their nipples are cracked or bleeding. It is not clear if this warning would apply to mothers who are being treated for hepatitis C.
Infants born to mothers with HCV infection should be tested for HCV infection; because maternal antibody is present for the first 18 months of life and before the infant mounts an immunologic response, nucleic acid testing is recommended.
Quoted from Daclatasvir — Drugs and Lactation Database (LactMed®), National Institute of Child Health and Human Development, revised August 15, 2025.
What LactMed would consider instead
LactMed ends this record by naming the drugs it would consider in place of daclatasvir. Whether any of them fits depends on what you are treating — this is the database’s list, not a recommendation from us.
- Interferon Alfa
- Interferon Alfacon-1
- Peginterferon Alfa
- Sofosbuvir
How much daclatasvir gets into breastmilk
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
What has been seen in breastfed infants
Relevant published information was not found as of the revision date.
Effects on milk supply
Relevant published information was not found as of the revision date.
Frequently asked questions
Can you take daclatasvir while breastfeeding?
Daclatasvir is no longer marketed in the United States. The full record is quoted on this page, and the decision is one to make with the person who prescribed it — LactMed itself states it is not a substitute for professional judgement.
What can I take instead of daclatasvir while breastfeeding?
LactMed lists Interferon Alfa, Interferon Alfacon-1, Peginterferon Alfa, Sofosbuvir as alternate drugs to consider. That is the database's own list for this drug — whether any of them suits you depends on what you are treating.
Does daclatasvir pass into breastmilk?
LactMed's measured drug levels for daclatasvir are quoted in full on this page, under "How much gets into breastmilk".
Do I need to pump and dump after taking daclatasvir?
LactMed does not frame its records that way — it reports measured drug levels in milk and what has been observed in breastfed infants, which is what this page quotes. "Pump and dump" advice for a specific drug and dose should come from your clinician or a pharmacist, not from a general rule.
More on daclatasvir
LactMed states that the information it presents is not a substitute for professional judgement, and that you should consult your healthcare provider for breastfeeding advice related to your particular situation. Nothing on this page is medical advice.