Can you take amiloride while breastfeeding?

What LactMed would consider instead

LactMed ends this record by naming the drugs it would consider in place of amiloride. Whether any of them fits depends on what you are treating — this is the database’s list, not a recommendation from us.

• Spironolactone

How much amiloride gets into breastmilk

Relevant published information was not found as of the revision date.

What has been seen in breastfed infants

Relevant published information was not found as of the revision date.

Effects on milk supply

Intense diuresis can suppress lactation; however, it is unlikely that amiloride alone is sufficiently potent to cause this effect.

A woman with Gitelman syndrome was prescribed amiloride 5 mg daily. She became pregnant and delivered a healthy infant. Amiloride was initially discontinued during breastfeeding, but restarted at 6 weeks postpartum. While on amiloride, the baby’s laboratory values showed a serum potassium of 5.8 mmol/L and a serum magnesium of 2.3 mg/dL. Spot urine concentrations of magnesium were < 1.4 mg/dL, urine creatinine was 5 mg/dL, and urine potassium was 5 mmol/L. Amiloride was stopped for one week and laboratory tests were repeated. Serum potassium was 4.8 mmol/L, magnesium was 2.2 mg/dL and a urine magnesium concentration was 1.7 mg/dL. Urine creatinine was 8 mg/dL, and urine potassium was 6 mmol/L.