Can you take agalsidase beta while breastfeeding?
What LactMed says
The National Library of Medicine’s own summary, quoted in full. We do not write a verdict of our own on this question, and we do not compress theirs into a label.
No information is available on the clinical use of agalsidase beta during breastfeeding. Because it is a large protein molecule with a molecular weight of about 100,000 Da, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Six infants who were breastfed for periods up to 12 months by mothers taking the closely related drug agalsidase alfa experienced no adverse effects associated with the drug.
Quoted from Agalsidase Beta — Drugs and Lactation Database (LactMed®), National Institute of Child Health and Human Development, revised August 15, 2023.
What LactMed would consider instead
LactMed ends this record by naming the drugs it would consider in place of agalsidase beta. Whether any of them fits depends on what you are treating — this is the database’s list, not a recommendation from us.
- Agalsidase Alfa
How much agalsidase beta gets into breastmilk
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
What has been seen in breastfed infants
Published information on agalsidase beta was not found as of the revision date. However, some information is available on the closely related drug agalsidase alfa. Six patients with Fabray disease were treated with agalsidase alfa 0.2 mg/kg every 2 weeks during pregnancy and postpartum. One infant partially breastfed for 10 months had asthma at age 4 years and an infant who was partially breastfed for 5 months had recurrent urinary tract infections up to 2 years, but was normal at the age of 5 years. Three infants who were exclusively breastfed for 6 months and partially breastfed until 12 months and one partially breastfed for 12 months were normal. None of the adverse effects appear to have been associated with agalsidase alfa.
Effects on milk supply
Relevant published information was not found as of the revision date.
Frequently asked questions
Can you take agalsidase beta while breastfeeding?
No information is available on the clinical use of agalsidase beta during breastfeeding. The full record is quoted on this page, and the decision is one to make with the person who prescribed it — LactMed itself states it is not a substitute for professional judgement.
What can I take instead of agalsidase beta while breastfeeding?
LactMed lists Agalsidase Alfa as alternate drugs to consider. That is the database's own list for this drug — whether any of them suits you depends on what you are treating.
Does agalsidase beta pass into breastmilk?
LactMed's measured drug levels for agalsidase beta are quoted in full on this page, under "How much gets into breastmilk".
Do I need to pump and dump after taking agalsidase beta?
LactMed does not frame its records that way — it reports measured drug levels in milk and what has been observed in breastfed infants, which is what this page quotes. "Pump and dump" advice for a specific drug and dose should come from your clinician or a pharmacist, not from a general rule.
More on agalsidase beta
LactMed states that the information it presents is not a substitute for professional judgement, and that you should consult your healthcare provider for breastfeeding advice related to your particular situation. Nothing on this page is medical advice.