Brand vs generic drugs: what's actually different?

A generic drug contains the same active ingredient as the brand-name original, at the same strength and in the same dosage form.

What must be the same

Before approval, the FDA requires a generic to be bioequivalent to the brand — it must deliver the same amount of active ingredient into the bloodstream in the same timeframe.

What can differ

• Inactive ingredients (fillers, dyes) — relevant if you have allergies.
• Appearance: shape, color, and markings often differ. That's normal.
• Price: generics are usually far cheaper once the brand's patent expires.

Bottom line

For most people, an FDA-approved generic works the same as the brand. Always talk to your pharmacist about any switch.