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Best Leukotriene Receptor Antagonist for asthma

Top-rated pick: Montelukast Sodium — pharmaranks score 72/100, the highest of the 2 Leukotriene Receptor Antagonist drugs used for asthma, ranked by our independent FDA recall-safety score. Compare them with all treatments for asthma or the full Leukotriene Receptor Antagonist class. Not medical advice — always consult a professional.

Quick answer: Of the 2 leukotriene receptor antagonist drugs we rate for asthma, 1 is available as lower-cost generics, and most are powder. Our ranking reflects each drug’s FDA recall-safety record — not clinical effectiveness for asthma; the right choice depends on your situation, so confirm it with your prescriber.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

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Top leukotriene receptor antagonist for asthma: 1. Montelukast Sodium · 2. Accolate

Best-rated Leukotriene Receptor Antagonist for asthma, ranked by pharmaranks score
#DrugRatingPharmacy pays
172/100View →
270/100$19View →

Full ranking · 2 drugs

Frequently asked

What is the best leukotriene receptor antagonist for asthma?
By our independent recall-safety rating — not an efficacy measure — montelukast sodium ranks highest among Leukotriene Receptor Antagonist drugs used for asthma. Always consult a professional.
Which leukotriene receptor antagonist drugs treat asthma?
pharmaranks lists 2 Leukotriene Receptor Antagonist products used for asthma, per NIH RxClass drug-classification data — each independently rated and ranked above.
How are these ranked?
By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.