Best Ergotamine Derivative for cluster headache
The 5 Ergotamine Derivative options we list for cluster headache are all Dihydroergotamine Mesylate— the same active ingredient in different brands or formulations, so they aren’t ranked against each other on effectiveness. Our score reflects each product’s FDA recall-safety record; the practical choice is brand vs generic, dose, and cost. Compare them with all treatments for cluster headache or the full Ergotamine Derivative class. Not medical advice — always consult a professional.
Quick answer: Of the 5 ergotamine derivative drugs we rate for cluster headache, all are available as lower-cost generics, and most are injectable. Our ranking reflects each drug’s FDA recall-safety record — not clinical effectiveness for cluster headache; the right choice depends on your situation, so confirm it with your prescriber.
Other drug classes for cluster headache
These are all Dihydroergotamine Mesylatein different brands or formulations, so we don’t rank them against each other — the list below is for comparing brand vs generic, dose, and typical cost, not for picking a “best” one on effectiveness.
All 5 ergotamine derivative products
brekiya (autoinjector)
Boxed warningPrescriptionFDA-sourced
Brekiya (Autoinjector) (Dihydroergotamine Mesylate) is an ergotamine derivative used to treat Cluster Headache, Postpartum Hemorrhage, Orthostatic Hypotension, Migraine Disorders.
Pharmacy pays
From ~$33.73· 2 formsatzumi
Boxed warningPrescriptionFDA-sourced
Atzumi (Dihydroergotamine Mesylate) is an ergotamine derivative used to treat Cluster Headache, Postpartum Hemorrhage, Orthostatic Hypotension, Migraine Disorders.
Pharmacy pays
From ~$33.73· 2 formsdihydroergotamine mesylate
Boxed warningPrescriptionFDA-sourced
Dihydroergotamine Mesylate is an ergotamine derivative used to treat Cluster Headache, Postpartum Hemorrhage, Orthostatic Hypotension, Migraine Disorders.
Pharmacy pays
From ~$33.73· 2 formsmigranal
Boxed warningPrescriptionFDA-sourced
Migranal (Dihydroergotamine Mesylate) is an ergotamine derivative used to treat Cluster Headache, Postpartum Hemorrhage, Orthostatic Hypotension, Migraine Disorders.
Pharmacy pays
From ~$33.73· 2 formstrudhesa
Boxed warningPrescriptionFDA-sourced
Trudhesa (Dihydroergotamine Mesylate) is an ergotamine derivative used to treat Cluster Headache, Postpartum Hemorrhage, Orthostatic Hypotension, Migraine Disorders.
Pharmacy pays
From ~$33.73· 2 formsFrequently asked
- What is the best ergotamine derivative for cluster headache?
- The Ergotamine Derivative options we list for cluster headache are all Dihydroergotamine Mesylate — the same active ingredient in different brands or formulations — so there's no single "best" one on effectiveness; the practical choice is brand vs generic, dose, and cost. Always consult a professional.
- Which ergotamine derivative drugs treat cluster headache?
- pharmaranks lists 5 Ergotamine Derivative products used for cluster headache, per NIH RxClass drug-classification data — each independently rated and ranked above.
- How are these ranked?
- By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.