Best Cholinesterase Inhibitor for myasthenia gravis
Top-rated pick: Neostigmine Methylsulfate — pharmaranks score 70/100, the highest of the 4 Cholinesterase Inhibitor drugs used for myasthenia gravis, ranked by our independent FDA recall-safety score. Compare them with all treatments for myasthenia gravis or the full Cholinesterase Inhibitor class. Not medical advice — always consult a professional.
Quick answer: Of the 4 cholinesterase inhibitor drugs we rate for myasthenia gravis, 3 are available as lower-cost generics, and most are injectable. Our ranking reflects each drug’s FDA recall-safety record — not clinical effectiveness for myasthenia gravis; the right choice depends on your situation, so confirm it with your prescriber.
How cholinesterase inhibitor work
Cholinesterase inhibitors block the enzyme that breaks down acetylcholine, a chemical messenger nerves use to communicate. By letting acetylcholine build up and act longer, they can help preserve memory and thinking in Alzheimer's disease, where this messenger runs low.
Source: Cholinesterase Inhibitors - StatPearls - NCBI Bookshelf
Other drug classes for myasthenia gravis
Top cholinesterase inhibitor for myasthenia gravis: 1. Neostigmine Methylsulfate · 2. Pyridostigmine Bromide · 3. Regonol
| # | Drug | Rating | Type | Form | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|
| 1 | 70/100 | Prescription | Injectable | No data | — | View → | |
| 2 | 70/100 | Prescription | Solution | Generic | $1 | View → | |
| 3 | 68/100 | Prescription | Injectable | Generic | $1 | View → | |
| 4 | Not yet rated | Prescription | Solution | Generic | $1 | View → |
Full ranking · 4 drugs
neostigmine methylsulfate
PrescriptionFDA-sourced
Neostigmine Methylsulfate is a cholinesterase inhibitor used to treat Drug-Induced Abnormalities, Urinary Bladder Diseases, Myasthenia Gravis, Urinary Retention.
Price varies
pyridostigmine bromide
PrescriptionFDA-sourced
Pyridostigmine Bromide is a cholinesterase inhibitor used to treat Drug-Induced Abnormalities, Myasthenia Gravis.
Pharmacy pays
From ~$0.57· 2 forms
regonol
PrescriptionFDA-sourced
Regonol (Pyridostigmine Bromide) is a cholinesterase inhibitor used to treat Drug-Induced Abnormalities, Myasthenia Gravis.
Pharmacy pays
From ~$0.57· 2 formsmestinon
PrescriptionFDA-sourced
Mestinon (Pyridostigmine Bromide) is a cholinesterase inhibitor used to treat Drug-Induced Abnormalities, Myasthenia Gravis.
Pharmacy pays
From ~$0.57· 2 formsFrequently asked
- What is the best cholinesterase inhibitor for myasthenia gravis?
- By our independent recall-safety rating — not an efficacy measure — neostigmine methylsulfate ranks highest among Cholinesterase Inhibitor drugs used for myasthenia gravis. Always consult a professional.
- Which cholinesterase inhibitor drugs treat myasthenia gravis?
- pharmaranks lists 4 Cholinesterase Inhibitor products used for myasthenia gravis, per NIH RxClass drug-classification data — each independently rated and ranked above.
- How are these ranked?
- By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.