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Best Aminosalicylate for proctitis

The 6 Aminosalicylate options we list for proctitis are all Mesalamine— the same active ingredient in different brands or formulations, so they aren’t ranked against each other on effectiveness. Our score reflects each product’s FDA recall-safety record; the practical choice is brand vs generic, dose, and cost. Compare them with all treatments for proctitis or the full Aminosalicylate class. Not medical advice — always consult a professional.

Quick answer: Of the 6 aminosalicylate drugs we rate for proctitis, all are available as lower-cost generics, and most are capsule. Our ranking reflects each drug’s FDA recall-safety record — not clinical effectiveness for proctitis; the right choice depends on your situation, so confirm it with your prescriber.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

How aminosalicylate work

Aminosalicylates (5-ASA drugs like mesalamine) act directly on the inflamed lining of the colon, where they are thought to calm the local inflammatory response by blocking several inflammation-driving chemicals and mopping up tissue-damaging free radicals, which helps the gut heal in ulcerative colitis.

Source: Mesalamine (USAN) - StatPearls - NCBI Bookshelf

These are all Mesalaminein different brands or formulations, so we don’t rank them against each other — the list below is for comparing brand vs generic, dose, and typical cost, not for picking a “best” one on effectiveness.

All 6 aminosalicylate products

ABBVIE logo
#1 of 7 in Aminosalicylate

canasa

PrescriptionFDA-sourced

72/100

Canasa (Mesalamine) is an aminosalicylate used to treat Ulcerative Colitis, Proctitis, Sigmoid Diseases.

(6 data points)
aminosalicylatecolitis, ulcerativeproctitis

Pharmacy pays

From ~$3.31/30· 8 forms Save up to 78% in class
View details →

apriso

PrescriptionFDA-sourced

New

Apriso (Mesalamine) is an aminosalicylate used to treat Ulcerative Colitis, Proctitis, Sigmoid Diseases.

aminosalicylatecolitis, ulcerativeproctitis

Pharmacy pays

From ~$3.31/30· 8 forms Save up to 78% in class
View details →
TAKEDA PHARMS USA logo

lialda

PrescriptionFDA-sourced

New

Lialda (Mesalamine) is an aminosalicylate used to treat Ulcerative Colitis, Proctitis, Sigmoid Diseases.

aminosalicylatecolitis, ulcerativeproctitis

Pharmacy pays

From ~$3.31/30· 8 forms Save up to 78% in class
View details →

mesalamine

PrescriptionFDA-sourced

New

Mesalamine is an aminosalicylate used to treat Ulcerative Colitis, Proctitis, Sigmoid Diseases.

aminosalicylatecolitis, ulcerativeproctitis

Pharmacy pays

From ~$3.31/30· 8 forms Save up to 78% in class
View details →
TAKEDA PHARMS USA logo

pentasa

PrescriptionFDA-sourced

New

Pentasa (Mesalamine) is an aminosalicylate used to treat Ulcerative Colitis, Proctitis, Sigmoid Diseases.

aminosalicylatecolitis, ulcerativeproctitis

Pharmacy pays

From ~$3.31/30· 8 forms Save up to 78% in class
View details →

sfrowasa

PrescriptionFDA-sourced

New

Sfrowasa (Mesalamine) is an aminosalicylate used to treat Ulcerative Colitis, Proctitis, Sigmoid Diseases.

aminosalicylatecolitis, ulcerativeproctitis

Pharmacy pays

From ~$3.31/30· 8 forms Save up to 78% in class
View details →

Frequently asked

What is the best aminosalicylate for proctitis?
The Aminosalicylate options we list for proctitis are all Mesalamine — the same active ingredient in different brands or formulations — so there's no single "best" one on effectiveness; the practical choice is brand vs generic, dose, and cost. Always consult a professional.
Which aminosalicylate drugs treat proctitis?
pharmaranks lists 6 Aminosalicylate products used for proctitis, per NIH RxClass drug-classification data — each independently rated and ranked above.
How are these ranked?
By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.