Atenolol: uses, dosing, side effects & brands
Atenolol is a beta-adrenergic blocker sold in the U.S. under 2 brand and generic names, for angina pectoris, atrial fibrillation and atrial flutter. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.
Key facts
- Drug class
- Beta-Adrenergic Blocker
- Treats
- Angina Pectoris, Atrial Fibrillation and Atrial Flutter
- Available as
- Tablet
- Sold as
- 2 products — Atenolol and Tenormin
- Prescription?
- Prescription only
- Generic available?
- Yes
- Half-life
- about 6 to 7 hours
- What the pharmacy pays
- about $0.76 for a 30-count supply — not your price
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How atenolol is dosed
From the FDA label for Atenolol (application ANDA073457). Other atenolol products — different forms, different strengths — are dosed differently. Follow the label for the one you were prescribed.
Hypertension The initial dose of atenolol is 50 mg given as one tablet a day either alone or added to diuretic therapy. The full effect of this dose will usually be seen within one to two weeks. If an optimal response is not achieved, the dosage should be increased to atenolol 100 mg given as one tablet a day. Increasing the dosage beyond 100 mg a day is unlikely to produce any further benefit. Atenolol tablets may be used alone or concomitantly with other antihypertensive agents including thiazide-type diuretics, hydralazine, prazosin, and alpha-methyldopa. Angina Pectoris The initial dose of atenolol is 50 mg given as one tablet a day. If an optimal response is not achieved within one week, the dosage should be increased to atenolol 100 mg given as one tablet a day. Some patients may require a dosage of 200 mg once a day for optimal effect. Twenty-four hour control with once daily dosing is achieved by giving doses larger than necessary to achieve an immediate maximum effect. The maximum early effect on exercise tolerance occurs with doses of 50 mg to 100 mg, but at these doses the effect at 24 hours is attenuated, averaging about 50% to 75% of that observed with once a day oral doses of 200 mg. Acute Myocardial Infarction In patients with definite or suspected acute myocardial infarction, treatment with atenolol I.V. injection should be initiated as soon as possible after…
Atenolol side effects
Most adverse effects have been mild and transient. The frequency estimates in the following table were derived from controlled studies in hypertensive patients in which adverse reactions were either volunteered by the patient (U.S. studies) or elicited, e.g., by checklist (foreign studies). The reported frequency of elicited adverse effects was higher for both atenolol tablets and placebo-treated patients than when these reactions were volunteered. Where frequency of adverse effects of atenolol tablets and placebo is similar, causal relationship to atenolol tablets is uncertain. Volunteered (U.S. Studies) Total-Volunteered and Elicited (Foreign + U.S. Studies) Atenolol (n = 164) % Placebo (n = 206) % Atenolol (n = 399) % Placebo (n = 407) % CARDIOVASCULAR Bradycardia 3 0 3 0 Cold Extremities 0 0.5 12 5 Postural Hypotension 2 1 4 5 Leg Pain 0 0.5 3 1 CENTRAL NERVOUS SYSTEM/NEUROMUSCULAR Dizziness 4 1 13 6 Vertigo 2 0.5 2 0.2 Light-headedness 1 0 3 0.7 Tiredness 0.6 0.5 26 13 Fatigue 3 1 6 5 Lethargy 1 0 3 0.7 Drowsiness 0.6 0 2 0.5 Depression 0.6 0.5 12 9 Dreaming 0 0 3 1 GASTROINTESTINAL Diarrhea 2 0 3 2 Nausea 4 1 3 1 RESPIRATORY (See WARNINGS ) Wheeziness 0 0 3 3 Dyspnea 0.6 1 6 4 Acute Myocardial Infarction In a series of investigations in the treatment of acute myocardial infarction, bradycardia and hypotension occurred more commonly, as expected for any beta-blocker, in…
Who shouldn’t take atenolol
Atenolol tablets are contraindicated in sinus bradycardia, heart block greater than first degree, cardiogenic shock, and overt cardiac failure. (See WARNINGS .) Atenolol tablets are contraindicated in those patients with a history of hypersensitivity to the atenolol or any of the drug product’s components.
Atenolol drug interactions
Catecholamine-depleting drugs (e.g., reserpine) may have an additive effect when given with beta-blocking agents. Patients treated with atenolol tablets plus a catecholamine depletor should therefore be closely observed for evidence of hypotension and/or marked bradycardia which may produce vertigo, syncope, or postural hypotension. Calcium channel blockers may also have an additive effect when given with atenolol tablets (see WARNINGS ). Disopyramide is a Type I antiarrhythmic drug with potent negative inotropic and chronotropic effects. Disopyramide has been associated with severe bradycardia, asystole and heart failure when administered with beta-blockers. Amiodarone is an antiarrhythmic agent with negative chronotropic properties that may be additive to those seen with beta-blockers. Beta-blockers may exacerbate the rebound hypertension which can follow the withdrawal of clonidine. If the two drugs are coadministered, the beta-blocker should be withdrawn several days before the gradual withdrawal of clonidine. If replacing clonidine by beta-blocker therapy, the introduction of beta-blockers should be delayed for several days after clonidine administration has stopped. Concomitant use of prostaglandin synthase inhibiting drugs, e.g., indomethacin, may decrease the hypotensive effects of beta-blockers. Information on concurrent usage of atenolol and aspirin is limited. Data from several studies, i.e., TIMI-II, ISIS-2, currently do not suggest any clinical interaction between aspirin and beta-blockers in the acute myocardial infarction setting. While taking beta-blockers, patients with a history of anaphylactic reaction to a variety of allergens may have a more severe reaction on repeated challenge, either accidental, diagnostic or therapeutic. Such patients may be unresponsive to the usual doses of epinephrine used to treat the allergic reaction. Both digitalis glycosides and beta-blockers slow atrioventricular conduction and decrease heart rate. Concomitant use can increase the risk of bradycardia.
Every atenolol product we track (2)
Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.
| # | Drug | Rating | Type | Form | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|
| 1 | 62/100 | Prescription | Tablet | Generic | $1 | View → | |
| 2 | Not yet rated | Prescription | Tablet | Generic | $1 | View → |
What atenolol pills look like
Imprint codes, colour and shape from the FDA’s labelling data. Match the imprint on your pill — or search any imprint.
| Imprint | Strength | Colour | Shape | Maker |
|---|---|---|---|---|
| RE;20 | 50 mg | white | round | — |
| Z;65 | 25 mg | white | round | — |
| ATN;25 | 25 mg | white | round | — |
| ATN;50 | 50 mg | white | round | — |
| M;231 | 50 mg | white | round | — |
| M;757 | 100 mg | white | round | — |
| M;A2 | 25 mg | white | round | — |
| U;22 | 25 mg | white | capsule | — |
| U;2;1 | 50 mg | white | round | — |
| U;20 | 100 mg | white | round | — |
| D;23 | 100 mg | white | round | — |
| Z;65 | 25 mg | white | round | — |
Combination products containing atenolol
A combination is a different drug — different dosing, different warnings. It is listed here so you can find it, not so you can substitute it.
How long does atenolol take to work?
“It may take 1-2 weeks before you feel the full benefit of atenolol.” — MedlinePlus, U.S. National Library of Medicine.
What the NIH says about how quickly atenolol worksHow long atenolol keeps
The date on a sealed pack is not the only one: some atenolol labels start a second clock once the product is opened or mixed, as short as 48 hours.
Does atenolol expire? The in-use limits and storage rules from its labelsAtenolol and breastfeeding
From LactMed, the US National Library of Medicine’s Drugs and Lactation Database — quoted, not rewritten.
Full LactMed record for atenolol: levels in milk, effects in breastfed infants, and the drugs it would consider insteadBecause of atenolol's relatively extensive excretion into breastmilk in the newborn period and its extensive renal excretion, other agents are preferred while nursing a newborn or preterm infant or with high maternal dosages. Infants older than 3 months of age appear to be at little risk of adverse effects from atenolol in breastmilk. Timing breastfeeding with respect to the time of the atenolol dose appears to be of little benefit in reducing infant atenolol exposure because it has a long half-life and the time of the peak level in milk is unpredictable.
National Institute of Child Health and Human Development, record revised December 15, 2025. LactMed states its information is not a substitute for professional judgement.
What people report to the FDA about atenolol
The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 128,379 reports naming atenolol, and the FDA flagged 70% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:
- nausea7,708 reports
- fatigue7,467 reports
- diarrhoea6,900 reports
- dizziness6,128 reports
- dyspnoea6,126 reports
- headache5,817 reports
- asthenia4,843 reports
- fall4,546 reports
Read these as a signal, not a rate. A report does not mean atenolol caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label section above.
Source: openFDA drug/event (FAERS), retrieved August 25, 2026.
How long atenolol stays in your system
The elimination half-life of atenolol is about 6 to 7 hours. Atenolol is cleared mainly by the kidneys and has no significant active metabolites, so the half-life is much longer in older adults and in people with reduced kidney function (roughly 16 to 27+ hours when creatinine clearance falls below about 35 mL/min).
Atenolol Tablets USP 25 mg, 50 mg and 100 mg (DailyMed FDA label) ↗Half-life is how long the body takes to clear half a dose. It is not the same as how long a drug test can detect it, and it varies with age, kidney and liver function.
Related calculators
Frequently asked questions
What is atenolol?
Atenolol is a beta-adrenergic blocker used to treat Angina Pectoris, Atrial Fibrillation, Atrial Flutter, Heart Failure.
What kind of drug is atenolol?
The FDA classifies atenolol as a beta-adrenergic blocker. Beta-blockers block adrenaline (epinephrine) and noradrenaline from acting on beta-adrenergic receptors, mainly in the heart. This slows the heart rate, reduces how forcefully the heart contracts, and lowers blood pressure, easing the workload on the heart. If you are checking whether it is safe to combine with something else, the class is what matters — two drugs from the same class usually should not be stacked.
How long does atenolol stay in your system?
The elimination half-life of atenolol is about 6 to 7 hours — that is how long the body takes to clear half of a dose. Atenolol is cleared mainly by the kidneys and has no significant active metabolites, so the half-life is much longer in older adults and in people with reduced kidney function (roughly 16 to 27+ hours when creatinine clearance falls below about 35 mL/min). Half-life is not the same as how long a drug test can detect the drug, and it varies with age, kidney and liver function.
Can you take atenolol with other medicines?
It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run atenolol against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.
What brand names is atenolol sold under?
We track 2 atenolol-containing products in the U.S.: Atenolol and Tenormin. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.
What forms does atenolol come in?
Across the brands we track, atenolol is currently marketed as tablet, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.
Is there a generic atenolol?
Yes. Our catalog lists 1 generic atenolol product alongside the brand versions. A generic has the same active ingredient and must meet the FDA's bioequivalence standard; it usually costs less. Ask your pharmacist which one your plan covers.
What are the common side effects of Tenormin (atenolol)?
As a beta blocker, Tenormin (atenolol) slows the heart and lowers blood pressure, so its most common side effects follow from that: tiredness, dizziness or lightheadedness (especially standing up too quickly), a slow heart rate, and cold hands and feet. MedlinePlus also lists depression, nausea, diarrhea, and dry eyes. The dizziness and faintness on standing are most common when you first start atenolol and often ease as your body adjusts. This is not a complete list of side effects.
Which Tenormin (atenolol) side effects mean I should call a doctor or get emergency care?
Get medical help right away for signs that atenolol has slowed the heart too much or triggered heart failure or breathing problems. MedlinePlus says to call your doctor or seek emergency treatment for "shortness of breath, wheezing, swelling of the hands, feet, ankles, or lower legs, unusual weight gain, fainting," and "rapid, pounding, or irregular heartbeat." Wheezing or shortness of breath matters especially if you have asthma or COPD: StatPearls notes atenolol "should...be avoided in individuals with a history of asthma, bronchospasm, or other obstructive airway diseases unless no alternative is available." A very slow heart rate with fainting is a medical emergency.
Can I stop taking Tenormin (atenolol) if I feel fine or get side effects?
No — do not stop Tenormin (atenolol) on your own, even if you feel well. Stopping a beta blocker suddenly can cause a dangerous rebound. StatPearls states atenolol "should not be discontinued abruptly, as doing so may worsen angina, acute myocardial infarction [heart attack], or ventricular arrhythmias." MedlinePlus likewise says to "continue to take atenolol even if you feel well" and not to stop "without talking to your doctor." If you and your doctor decide to stop, the dose is tapered down gradually over time rather than halted at once.
Does Tenormin (atenolol) build up if I have kidney problems, and can it hide low blood sugar?
Yes to both, which is why atenolol needs extra caution in certain patients. Atenolol is cleared mainly by the kidneys, so it accumulates when kidney function is reduced: StatPearls notes "impaired glomerular function leads to a substantial accumulation of the drug," and doses are capped by kidney function (for example, a maximum of 50 mg daily at a creatinine clearance of 10–30 mL/min and 25 mg daily below 10 mL/min). In people with diabetes, beta blockers can mask the warning signs of low blood sugar — StatPearls advises caution "due to the potential for masking the symptoms of hypoglycemia" such as a racing heartbeat (in general, sweating is usually still noticeable).
When do Tenormin (atenolol) side effects start, and how long do they last?
Blood-pressure–lowering effects and side effects like dizziness or tiredness can begin within hours of the first doses, and MedlinePlus notes lightheadedness on standing is "more common when you first start taking atenolol." The full benefit on blood pressure may take 1–2 weeks. Many early side effects settle as your body adjusts; ones that persist or worsen should be reported to your doctor rather than managed by stopping the drug. This overview does not cover every possible side effect — check the FDA label and ask your prescriber or pharmacist about your specific situation.
What is atenolol used for?
Atenolol is a beta-blocker that slows the heart rate and lowers blood pressure. Its FDA-approved uses are treating high blood pressure (hypertension), managing chronic chest pain from reduced blood flow (angina pectoris), and treating people during and after a heart attack (acute myocardial infarction) to improve survival. It works by blocking the effect of adrenaline on the heart, so the heart beats more slowly and with less force.
Is atenolol used for anxiety or migraines?
Sometimes, but these are off-label uses not listed in the FDA labeling. Because atenolol blunts the physical symptoms of adrenaline — racing heart, shaking hands, trembling voice — doctors occasionally prescribe it off-label for performance or situational anxiety (for example before a speech or performance). It is also used off-label to help prevent migraines, though the related beta-blockers propranolol and timolol are the ones FDA-approved for migraine prevention. Talk to your prescriber before using atenolol for either purpose.
Does atenolol lower heart rate?
Yes. Lowering heart rate is a core part of how atenolol works. By blocking beta-1 receptors in the heart, it reduces how fast and how forcefully the heart beats, which lowers blood pressure and eases the heart's workload during angina. Because of this effect, your prescriber may check your pulse; a resting heart rate that drops too low (bradycardia) can cause dizziness or fatigue and should be reported. Do not stop atenolol suddenly, as this can trigger a rebound spike in heart rate and blood pressure.
Cite this page
- APA
- pharmaranks. (2026, July 24). Atenolol: uses, dosing, side effects & brands. https://pharmaranks.com/drugs/atenolol
- MLA
- “Atenolol: uses, dosing, side effects & brands.” pharmaranks, 24 July 2026, https://pharmaranks.com/drugs/atenolol.
We summarise public FDA and NIH sources — for a clinical claim, cite the primary source we link to as well.
Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.
Read the full FDA label for atenolol on DailyMed (NIH) ↗.