Strep throat is a bacterial infection (group A strep) confirmed by a rapid test or culture — a sore throat alone is often viral and doesn't need antibiotics. When strep is confirmed, penicillin-class antibiotics are first-line.
What guidelines recommend to try first. Tap one we rate for its independent monograph.
Penicillin
First-line per CDC — reliable activity against group A strep, and resistance to penicillin has not been documented.
First-line and often preferred for children for taste and dosing.
Cephalexin
A first-choice for many penicillin-allergic patients (non-severe allergy).
An option for penicillin allergy.
Azithromycin
A macrolide option for penicillin allergy.
CDC — Antibiotic Prescribing and Use: Outpatient Clinical Care for Adults ↗
General reference, not medical advice. Antibiotics are prescription-only; the right one depends on the specific infection, local resistance, your allergies, and your clinician’s judgment. Don’t self-treat, and never use leftover antibiotics or someone else’s — that drives resistance and can be dangerous. See a licensed clinician.