Econazole: uses, dosing, side effects & brands
Econazole is an azole antifungal sold in the U.S. under 3 brand and generic names, for cutaneous candidiasis, tinea pedis and tinea versicolor. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.
Key facts
- Drug class
- Azole Antifungal
- Treats (across its forms)
- Cutaneous Candidiasis, Tinea Pedis and Tinea Versicolor
- Available as
- Topical · Spray/Inhaler
- Sold as
- 3 products — Spectazole, Econazole Nitrate and Ecoza
- Prescription?
- Prescription only
- Generic available?
- Yes
- What the pharmacy pays
- about $0.36 per gm — not your price
How econazole is dosed
From the FDA label for Ecoza (application NDA205175). Other econazole products — different forms, different strengths — are dosed differently. Follow the label for the one you were prescribed.
Ecoza topical foam, 1% is for topical use only. Ecoza topical foam, 1% is not for oral, ophthalmic, or intravaginal use. Ecoza topical foam, 1% should be applied to cover affected areas once daily for 4 weeks. For topical use only; not for oral, ophthalmic, or intravaginal use. ( 2 ) Apply once daily for 4 weeks. ( 2 )
Econazole side effects
During clinical trials with Ecoza topical foam, the most common adverse reactions were application site reactions which occurred in less than 1% of subjects in both the Ecoza and vehicle arms. ( 6.1 ) To report SUSPECTED ADVERSE REACTIONS, contact Resilia Pharmaceuticals at 1-888-998-0770 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. In two double-blind, vehicle-controlled clinical trials, 495 subjects were exposed to Ecoza topical foam or vehicle (246 subjects were exposed to Ecoza topical foam, 1% and 249 were exposed to vehicle). Subjects with interdigital tinea pedis applied foam or vehicle once daily for approximately 28 days. During clinical trials with Ecoza topical foam, the most common adverse reactions were application site reactions which occurred in less than 1% of subjects in both the Ecoza and vehicle arms.
Who shouldn’t take econazole
None. None. ( 4 )
Econazole drug interactions
7.1 Warfarin Concomitant administration of econazole and warfarin has resulted in enhancement of anticoagulant effect. Most cases reported product application with use under occlusion, genital application, or application to a large body surface area which may increase the systemic absorption of econazole nitrate. Monitoring of International Normalized Ratio (INR) and/or prothrombin time may be indicated especially for patients who apply econazole to large body surface areas, in the genital area, or under occlusion.
Every econazole product we track (3)
Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.
| # | Drug | Rating | Type | Form | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|
| 1 | 70/100 | Prescription | Topical | Generic | $0 | View → | |
| 2 | Not yet rated | Prescription | Topical | Generic | $0 | View → | |
| 3 | Not yet rated | Prescription | Topical | Generic | $0 | View → |
How long econazole keeps
No econazole label we read sets a separate limit for after opening, but they do specify how it must be stored — and the stability behind any date assumes those conditions.
Does econazole expire? The in-use limits and storage rules from its labelsEconazole and breastfeeding
From LactMed, the US National Library of Medicine’s Drugs and Lactation Database — quoted, not rewritten.
Full LactMed record for econazole: levels in milk, effects in breastfed infants, and the drugs it would consider insteadTopical econazole has not been studied during breastfeeding. Because less than 1% is absorbed after topical application, it is considered a low risk to the nursing infant. Avoid application to the nipple area and ensure that the infant's skin does not come into direct contact with the areas of skin that have been treated. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.
National Institute of Child Health and Human Development, record revised November 15, 2024. LactMed states its information is not a substitute for professional judgement.
What people report to the FDA about econazole
The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 1,005 reports naming econazole, and the FDA flagged 67% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:
- fatigue63 reports
- rash53 reports
- dyspnoea50 reports
- diarrhoea47 reports
- nausea47 reports
- dizziness43 reports
- pruritus40 reports
- pyrexia40 reports
Read these as a signal, not a rate. A report does not mean econazole caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label section above.
Source: openFDA drug/event (FAERS), retrieved July 25, 2026.
Related calculators
Frequently asked questions
What is econazole?
Ecoza (econazole nitrate) topical foam, 1% contains the azole antifungal agent, econazole nitrate in an oil-in-water emulsion base consisting of the following inactive ingredients: dimethicone, glycerin, polysorbate 20, povidone, propylene glycol, stearic acid, trolamine, purified water and butane as a propellant.
What kind of drug is econazole?
The FDA classifies econazole as an azole antifungal. Azole antifungals block a fungal enzyme (lanosterol 14-alpha-demethylase) that the fungus needs to make ergosterol, a key building block of its cell membrane. Without enough ergosterol the membrane becomes leaky and unstable, which stops the fungus from growing and can cause it to break apart and die. If you are checking whether it is safe to combine with something else, the class is what matters — two drugs from the same class usually should not be stacked.
Can you take econazole with other medicines?
It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run econazole against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.
What brand names is econazole sold under?
We track 3 econazole-containing products in the U.S.: Spectazole, Econazole Nitrate and Ecoza. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.
What forms does econazole come in?
Across the brands we track, econazole is currently marketed as topical and spray/inhaler, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.
Is there a generic econazole?
Yes. Our catalog lists 1 generic econazole product alongside the brand versions. A generic has the same active ingredient and must meet the FDA's bioequivalence standard; it usually costs less. Ask your pharmacist which one your plan covers.
Cite this page
- APA
- pharmaranks. (2026, July 24). Econazole: uses, dosing, side effects & brands. https://pharmaranks.com/drugs/econazole
- MLA
- “Econazole: uses, dosing, side effects & brands.” pharmaranks, 24 July 2026, https://pharmaranks.com/drugs/econazole.
We summarise public FDA and NIH sources — for a clinical claim, cite the primary source we link to as well.
Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.
Read the full FDA label for econazole on DailyMed (NIH) ↗.