ALOPRIM (allopurinol) for Injection, a xanthine oxidase inhibitor, is a sterile, white, lyophilized powder or cake, in a single-dose vial for reconstitution. Each vial contains 500 mg of allopurinol equivalent to 580.7 mg of allopurinol sodium and 148 mg of sodium hydroxide as a solubilizer. Sodium hydroxide is also used as a pH adjuster. ALOPRIM (allopurinol) for Injection contains no preservatives. Allopurinol is a xanthine oxidase inhibitor. The chemical name for allopurinol sodium is 1,5-dihydro-4 H -pyrazolo[3,4- d ]pyrimidin-4-one monosodium salt. It is a white amorphous mass with a molecular weight of 158.09 and molecular formula C 5 H 3 N 4 NaO. The structural formula is: The pKa of allopurinol sodium is 9.31. Allopurinol Structural Formula

What kind of drug is allopurinol?

The FDA classifies allopurinol as a xanthine oxidase inhibitor. If you are checking whether it is safe to combine with something else, the class is what matters — two drugs from the same class usually should not be stacked.

Can you take allopurinol with other medicines?

It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run allopurinol against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.

What brand names is allopurinol sold under?

We track 3 allopurinol-containing products in the U.S.: Aloprim, Allopurinol and Zyloprim. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.

What forms does allopurinol come in?

Across the brands we track, allopurinol is currently marketed as injectable and tablet, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.

Is there a generic allopurinol?

Yes. Our catalog lists 1 generic allopurinol product alongside the brand versions. A generic has the same active ingredient and must meet the FDA's bioequivalence standard; it usually costs less. Ask your pharmacist which one your plan covers.

Has allopurinol been recalled?

The FDA's Enforcement database lists 1 recall record whose product description mentions allopurinol. The most recent: Allopurinol Tablets (Jun 7, 2024). A recall applies to specific lots, not to the drug as a whole — check the record for the affected lot numbers.

Allopurinol: uses, dosing, side effects & brands

Allopurinol is a xanthine oxidase inhibitor sold in the U.S. under 3 brand and generic names, for gout. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.

By the pharmaranks editorial teamReviewed against the FDA (openFDA label, NDC Directory & Enforcement) sourcesHow we research

Key facts

Drug class: Xanthine Oxidase Inhibitor
Treats: Gout
Available as: Injectable · Tablet
Sold as: 3 products — Aloprim, Allopurinol and Zyloprim
Prescription?: Prescription only
Generic available?: Yes
Typical price: about $2 for a 30-count supply

How allopurinol is dosed

From the FDA label for Aloprim (application NDA020298). Other allopurinol products — different forms, different strengths — are dosed differently. Follow the label for the one you were prescribed.

Recommended Dosage ( 2.2 ) Adult Patients 200 mg/m 2 /day to 400 mg/m 2 /day Maximum 600 mg/day Pediatric Patients Starting Dose 200 mg/m 2 /day Maximum 400 mg/day • Recommended Dosage in Adult Patients with Renal Impairment ( 2.2 , 5.2 , 8.6 ) Creatinine Clearance Recommended Daily Dose 10 to 20 mL/min 200 mg/day Less than 10 mL/min 100 mg/day On dialysis 50 mg every 12 hours, or 100 mg every 24 hours 2.1 Recommended Dosage Initiate therapy with ALOPRIM 24 to 48 hours before the start of chemotherapy known to cause tumor cell lysis. Additionally, administer fluids sufficient to yield a daily urinary output of at least two liters in adults with a neutral or, preferably, slightly alkaline urine. The recommended daily dose of ALOPRIM is shown in Table 1. Administer the daily dose as single infusion or in equally divided infusions at 6-, 8-, or 12-hour intervals at a rate appropriate for the volume of infusate. Table 1: Recommended Daily Dose of ALOPRIM Adult Patients 200 mg/m 2 /day to 400 mg/m 2 /day intravenously Maximum 600 mg/day Pediatric Patients Starting Dose 200 mg/m 2 /day intravenously Maximum 400 mg/day The dosage of ALOPRIM to lower serum uric acid to normal or near-normal varies with the severity of the disease. Monitor serum uric acid levels at least daily and administer ALOPRIM at a dose and frequency to maintain the serum uric acid…

Allopurinol side effects

The following clinically significant adverse reactions are described elsewhere in the labeling: • Skin Rash and Hypersensitivity [see Warnings and Precautions (5.1) ] • Renal Function Impairment [see Warnings and Precautions (5.2) ] • Hepatoxicity [see Warnings and Precautions (5.3) ] • Myelosuppression [see Warnings and Precautions (5.4) ] • Drowsiness [see Warnings and Precautions (5.5) ] Most common adverse reactions (incidence > 1%) are skin rash, nausea, vomiting, and renal failure/insufficiency. ( 6.1 ) To report SUSPECTED ADVERSE REACTIONS, contact Mylan at 1-877-446-3679 (1-877-4-INFO-RX) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. The safety of ALOPRIM was evaluated in an uncontrolled compassionate use study of 1,378 patients with advanced malignancies requiring treatment with cytotoxic chemotherapy and in patients with other serious conditions. Adverse reactions were reported in 9% (125/1378) of the patients treated with ALOPRIM. The most common adverse reaction was skin rash. Two patients experience serious adverse reactions (decreased renal function and generalized…

Every allopurinol product we track (3)

Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.

Allopurinol products
#	Drug	Rating	Type	Form	Generic?	Typical price
1	Aloprim	60/100	Prescription	Injectable	Generic	$2	View →
2	Allopurinol	Not yet rated	Prescription	Injectable	Generic	$2

What allopurinol pills look like

Imprint codes, colour and shape from the FDA’s labelling data. Match the imprint on your pill — or search any imprint.

Allopurinol pill imprints
Imprint	Strength	Colour	Shape	Maker
349;U	100 mg	white	round	—
I;136	300 mg	pink	capsule	—
MP;71	100 mg	white	round	—
2083;V	100 mg	white	round	—
2084;V	300 mg	orange	round	—
I;135	100 mg

Combination products containing allopurinol

A combination is a different drug — different dosing, different warnings. It is listed here so you can find it, not so you can substitute it.

Duzallo

Allopurinol recalls

From the FDA Enforcement database. A recall covers specific lots — not the drug as a whole.

Allopurinol Tablets
Presence of foreign substance.
Dr. Reddy's Laboratories, Inc. · Jun 7, 2024

Frequently asked questions

What is allopurinol?: ALOPRIM (allopurinol) for Injection, a xanthine oxidase inhibitor, is a sterile, white, lyophilized powder or cake, in a single-dose vial for reconstitution. Each vial contains 500 mg of allopurinol equivalent to 580.7 mg of allopurinol sodium and 148 mg of sodium hydroxide as a solubilizer. Sodium hydroxide is also used as a pH adjuster. ALOPRIM (allopurinol) for Injection contains no preservatives. Allopurinol is a xanthine oxidase inhibitor. The chemical name for allopurinol sodium is 1,5-dihydro-4 H -pyrazolo[3,4- d ]pyrimidin-4-one monosodium salt. It is a white amorphous mass with a molecular weight of 158.09 and molecular formula C 5 H 3 N 4 NaO. The structural formula is: The pKa of allopurinol sodium is 9.31. Allopurinol Structural Formula
What kind of drug is allopurinol?: The FDA classifies allopurinol as a xanthine oxidase inhibitor. If you are checking whether it is safe to combine with something else, the class is what matters — two drugs from the same class usually should not be stacked.
Can you take allopurinol with other medicines?: It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run allopurinol against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.
What brand names is allopurinol sold under?: We track 3 allopurinol-containing products in the U.S.: Aloprim, Allopurinol and Zyloprim. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.
What forms does allopurinol come in?: Across the brands we track, allopurinol is currently marketed as injectable and tablet, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.

Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.