What is the difference between Adcirca and Adderall XR?

ADCIRCA vs ADDERALL XR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated July 13, 2026·How we rate

Possible drug interaction. ADCIRCA and ADDERALL XR are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ADCIRCA	ADDERALL XR
Rating	72/100	New
Pharmacy pays	~$4.64 /30	—
Type	RX	RX
Active ingredient	TADALAFIL	DEXTROAMPHETAMINE SULFATE, DEXTROAMPHETAMINE SACCHARATE, AMPHETAMINE SULFATE AND AMPHETAMINE ASPARTATE
Manufacturer	Eli Lilly Co	Takeda Pharms USA
Dosage forms	Tablet	Capsule, extended release
Drug class	Phosphodiesterase 5 Inhibitor	—
Boxed warning	None	Boxed warning
Half-life	about 17.5 hours	about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults
Treats	Pulmonary Hypertension, Vasculogenic Impotence	—

adcirca adderall xr

Rating

72/100

New

Pharmacy pays

~$4.64 /30

—

Type

Active ingredient

TADALAFIL

DEXTROAMPHETAMINE SULFATE, DEXTROAMPHETAMINE SACCHARATE, AMPHETAMINE SULFATE AND AMPHETAMINE ASPARTATE

Manufacturer

Eli Lilly Co

Takeda Pharms USA

Dosage forms

Tablet

Capsule, extended release

Drug class

Phosphodiesterase 5 Inhibitor

—

Boxed warning

None

Boxed warning

Half-life

about 17.5 hours

about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults

Treats

Pulmonary Hypertension, Vasculogenic Impotence

—

Frequently asked questions

What is the difference between Adcirca and Adderall XR?: Adcirca contains Tadalafil, while Adderall XR contains Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate and Amphetamine Aspartate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.