Torsemide, USP is a diuretic of the pyridine-sulfonylurea class. Its chemical name is 1-isopropyl-3-[(4-m-toluidino-3-pyridyl) sulfonyl]urea and its structural formula is: Its molecular formula is C 16 H 20 N 4 O 3 S, its pKa is 7.1, and its molecular weight is 348.43. Torsemide, USP is a white to off-white crystalline powder. The tablet for oral administration contains 5 mg, 10 mg, 20 mg or 100 mg of torsemide. In addition, each tablet contains the following inactive ingredients: colloidal silicon dioxide, crospovidone, lactose monohydrate, magnesium stearate, and microcrystalline cellulose. Meets USP Dissolution Test 2.

What kind of drug is torsemide?

The FDA classifies torsemide as a loop diuretic. Loop diuretics such as furosemide block a salt-transport protein (the Na-K-2Cl cotransporter) in a part of the kidney called the loop of Henle. This stops sodium and chloride from being reabsorbed, so the body flushes out extra salt and water, relieving fluid buildup and swelling. If you are checking whether it is safe to combine with something else, the class is what matters — two drugs from the same class usually should not be stacked.

Can you take torsemide with other medicines?

It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run torsemide against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.

What brand names is torsemide sold under?

We track 2 torsemide-containing products in the U.S.: Demadex and Soaanz. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.

What forms does torsemide come in?

Across the brands we track, torsemide is currently marketed as tablet and solution, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.

Is there a generic torsemide?

We do not currently list a generic-labelled torsemide product. That does not always mean none exists — it means none appears under a generic name in the FDA data we track. Ask your pharmacist.

Torsemide: uses, dosing, side effects & brands

Torsemide is a loop diuretic sold in the U.S. under 2 brand and generic names, for ascites, edema and heart failure. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.

By the pharmaranks editorial teamReviewed against the FDA (openFDA label, NDC Directory & Enforcement) sourcesHow we research

Key facts

Drug class: Loop Diuretic
Treats: Ascites, Edema and Heart Failure
Available as: Tablet · Solution
Sold as: 2 products — Demadex and Soaanz
Prescription?: Prescription only
Generic available?: Not in our catalog
Typical price: about $2 for a 30-count supply

How torsemide is dosed

From the FDA label for Soaanz (application NDA213218). Other torsemide products — different forms, different strengths — are dosed differently. Follow the label for the one you were prescribed.

Edema associated with: Heart failure: Initial dose is 10 or 20 mg once daily. Titrate by factors of two; doses above 200 mg have not been studied. ( 2.1 ) Chronic Renal Failure: Initial dose is 20 mg once daily. Titrate by factors of two; doses above 200 mg have not been studied. ( 2.1 ) Hepatic Cirrhosis: Initial dose is 5 or 10 mg once daily. Titrate by factors of two; doses above 40 mg have not been studied. ( 2.1 ) Hypertension: The recommended initial dose is 5 mg once daily. After 4 to 6 weeks, increase to 10 mg once daily, if needed. If 10 mg is insufficient, consider adding another agent. ( 2.2 ) 2.1 Treatment of Edema Edema associated with heart failure The recommended initial dose is 10 mg or 20 mg oral torsemide once daily. If the diuretic response is inadequate, titrate upward by approximately doubling until the desired diuretic response is obtained. Doses higher than 200 mg have not been adequately studied. Edema associated with chronic renal failure The recommended initial dose is 20 mg oral torsemide once daily. If the diuretic response is inadequate, titrate upward by approximately doubling until the desired diuretic response is obtained. Doses higher than 200 mg have not been adequately studied. Edema associated with hepatic cirrhosis The recommended initial dose is 5 mg or 10 mg oral torsemide once daily, administered together with an aldosterone antagonist…

Torsemide side effects

The following risks are discussed in more detail in others sections: Hypotension and Worsening Renal Function [see Warnings and Precautions (5.1) ] Electrolyte and Metabolic Abnormalities [see Warnings and Precautions (5.2) ] Ototoxicity [see Warnings and Precautions (5.3) ] The most common adverse reaction is excessive urination (6.7%). ( 6.1 ) To report SUSPECTED ADVERSE REACTIONS, contact Avet Pharmaceuticals Inc. at 1-866-901-DRUG (3784) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. In pre-approval studies, torsemide has been evaluated for safety in approximately 4,000 subjects; over 800 of these subjects received torsemide for at least 6 months, and over 380 were treated for more than 1 year. Among these subjects were 564 who received torsemide during United States-based trials in which 274 other subjects received placebo. Discontinuation of therapy due to adverse reactions occurred in 3.5% of United States patients treated with torsemide and in 4.4% of patients treated with placebo. In United States placebo-controlled trials excessive urination occurred in 6.7% of patients…

Every torsemide product we track (2)

Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.

Torsemide products
#	Drug	Rating	Type	Form	Generic?	Typical price
1	Demadex	Not yet rated	Prescription	Tablet	Generic	$2	View →
2	Soaanz	Not yet rated	Prescription	Tablet	Generic	$2	View →

What torsemide pills look like

Imprint codes, colour and shape from the FDA’s labelling data. Match the imprint on your pill — or search any imprint.

Torsemide pill imprints
Imprint	Strength	Colour	Shape	Maker
59;H	20 mg	white	oval	—
PA;918	100 mg	white	oval	—
PA;915	5 mg	white	round	—
PA;916	10 mg	white	round	—
PA;917	20 mg	white	round	—
54;017	20 mg	white

Frequently asked questions

What is torsemide?: Torsemide, USP is a diuretic of the pyridine-sulfonylurea class. Its chemical name is 1-isopropyl-3-[(4-m-toluidino-3-pyridyl) sulfonyl]urea and its structural formula is: Its molecular formula is C 16 H 20 N 4 O 3 S, its pKa is 7.1, and its molecular weight is 348.43. Torsemide, USP is a white to off-white crystalline powder. The tablet for oral administration contains 5 mg, 10 mg, 20 mg or 100 mg of torsemide. In addition, each tablet contains the following inactive ingredients: colloidal silicon dioxide, crospovidone, lactose monohydrate, magnesium stearate, and microcrystalline cellulose. Meets USP Dissolution Test 2.
What kind of drug is torsemide?: The FDA classifies torsemide as a loop diuretic. Loop diuretics such as furosemide block a salt-transport protein (the Na-K-2Cl cotransporter) in a part of the kidney called the loop of Henle. This stops sodium and chloride from being reabsorbed, so the body flushes out extra salt and water, relieving fluid buildup and swelling. If you are checking whether it is safe to combine with something else, the class is what matters — two drugs from the same class usually should not be stacked.
Can you take torsemide with other medicines?: It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run torsemide against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.
What brand names is torsemide sold under?: We track 2 torsemide-containing products in the U.S.: Demadex and Soaanz. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.
What forms does torsemide come in?: Across the brands we track, torsemide is currently marketed as tablet and solution, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.

Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.

Torsemide drug interactions

Non-steroidal anti-inflammatory drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects; risk of renal impairment. ( 7.1 ) CYP2C9: Concomitant use with CYP2C9 inhibitors can decrease torsemide clearance. Torsemide may affect the efficacy and safety of sensitive CYP2C9 substrates or of substrates with a narrow therapeutic range, such as warfarin or phenytoin. ( 7.2 ) Cholestyramine: Decreased exposure of torsemide. ( 7.3 ) Organic anion drugs: may decrease diuretic activity of torsemide. ( 7.4 ) Lithium: Risk of lithium toxicity ( 7.5 ) Renin-angiotensin inhibitors: Increased risk of hypotension and renal impairment. ( 7.7 ) Radiocontrast agents: Increased risk of renal toxicity. ( 7.8 ) Corticosteroids and ACTH: Increased risk of hypokalemia. ( 7.9 ) 7.1 Nonsteroidal Anti-inflammatory Drugs Because torsemide and salicylates compete for secretion by renal tubules, patients receiving high doses of salicylates may experience salicylate toxicity when torsemide is concomitantly administered. Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) and torsemide has been associated with the development of acute renal failure. The antihypertensive and diuretic effects of torsemide can be reduced by NSAIDs. Partial inhibition of the natriuretic effect of torsemide by concomitant administration of indomethacin has been demonstrated for torsemide under…