Testosterone Enanthate: uses, dosing, side effects & brands

Q: What is testosterone enanthate?

XYOSTED (testosterone enanthate) injection contains testosterone enanthate, an ester derivative of an endogenous androgen, testosterone.

Q: What kind of drug is testosterone enanthate?

The FDA classifies testosterone enanthate as an androgen. Androgens such as testosterone are male sex hormones that enter cells and bind the androgen receptor, switching on genes that drive male traits, muscle and bone growth, and reproductive function. Some testosterone is also converted in tissues to the more potent DHT. If you are checking whether it is safe to combine with something else, the class is what matters — two drugs from the same class usually should not be stacked.

Q: How long does testosterone enanthate stay in your system?

The elimination half-life of testosterone enanthate is about 10 to 100 minutes — that is how long the body takes to clear half of a dose. This is the half-life of the natural testosterone hormone itself. The FDA label notes "considerable variation... ranging from 10 to 100 minutes," reflecting how quickly free testosterone is cleared. Two caveats matter for "how long it stays in your system": (1) Formulation dominates. Injectable esters are slow-release depots that far outlast the hormone's own half-life — testosterone cypionate ~8 days, enanthate ~4.5 days, undecanoate weeks — and oral testosterone undecanoate (Jatenzo, Kyzatrex) is a prodrug cleaved to testosterone. The 10-100 minute figure is the hormone's intrinsic clearance, not the duration of a shot. (2) Testosterone converts to active metabolites — dihydrotestosterone (DHT) and estradiol — that circulate on their own timelines. Inactivation occurs primarily in the liver, so hepatic impairment can slow clearance; ~90% is excreted in urine as conjugates. Half-life is not the drug-test detection window: anti-doping tests use the testosterone/epitestosterone ratio and isotope analysis and can flag use for far longer than clearance of the hormone. Half-life is not the same as how long a drug test can detect the drug, and it varies with age, kidney and liver function.

Q: Can you take testosterone enanthate with other medicines?

It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run testosterone enanthate against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.

Q: What brand names is testosterone enanthate sold under?

We track 2 testosterone enanthate-containing products in the U.S.: Delatestryl and Xyosted (Autoinjector). They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.

Q: What forms does testosterone enanthate come in?

Across the brands we track, testosterone enanthate is currently marketed as injectable, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.

Q: Is there a generic testosterone enanthate?

We do not currently list a generic-labelled testosterone enanthate product. That does not always mean none exists — it means none appears under a generic name in the FDA data we track. Ask your pharmacist.

Testosterone Enanthate is an androgen sold in the U.S. under 2 brand and generic names, for breast neoplasms, hypogonadism and delayed puberty. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.

By the pharmaranks editorial teamReviewed against the FDA (openFDA label, NDC Directory & Enforcement) sourcesUpdated Jul 24, 2026How we research

Key facts

Drug class: Androgen
Treats: Breast Neoplasms, Hypogonadism and Delayed Puberty
Available as: Injectable
Sold as: 2 products — Delatestryl and Xyosted (Autoinjector)
Prescription?: Prescription only
Generic available?: Not in our catalog
Half-life: about 10 to 100 minutes

How testosterone enanthate is dosed

From the FDA label for Xyosted (Autoinjector) (application NDA209863). Other testosterone enanthate products — different forms, different strengths — are dosed differently. Follow the label for the one you were prescribed.

Prior to initiating XYOSTED : confirm the diagnosis of hypogonadism by ensuring that serum testosterone has been measured in the morning on at least two separate days and that these concentrations are below the normal range ( 2.1 ). Starting dose: 75 mg subcutaneously in the abdominal region once weekly. Avoid intramuscular and intravascular administration ( 2.2 , 2.3 ). Dose Adjustment: Based upon total testosterone trough concentrations (measured 7 days after most recent dose) obtained following 6 weeks of dosing and periodically thereafter ( 2.2 ). Discard unused portion ( 2.3 ) 2.1 Confirmation of Hypogonadism Before Initiation of XYOSTED Prior to initiating XYOSTED, confirm the diagnosis of hypogonadism by ensuring that serum testosterone concentrations have been measured in the morning on at least two separate days and that these serum testosterone concentrations are below the normal range. 2.2 Starting Dose and Dose Adjustment The starting dose of XYOSTED is 75 mg, administered subcutaneously in the abdominal region once a week. Dose adjustment Measure total testosterone trough concentrations (measured 7 days after the most recent dose) following 6 weeks of dosing, following 6 weeks after dose adjustment, and periodically while on treatment with XYOSTED. A trough concentration between 350 ng/dL and 650 ng/dL generally provides testosterone exposures in the normal range…

Testosterone Enanthate side effects

The most commonly reported adverse reactions (>5%) were: hematocrit increased, hypertension, PSA increased, injection site bruising, and headache. ( 6.1 ) To report SUSPECTED ADVERSE REACTIONS, contact Antares at 1-844-XYOSTED (1-844-996-7833) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch . 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice. The safety of XYOSTED was evaluated in 2 clinical studies in a total of 283 men who received weekly subcutaneous doses for up to one year. All patients were started on 75 mg weekly, then the dose was titrated to 50 mg or 100 mg weekly, as needed, to achieve pre-dose total testosterone concentrations of ≥350 ng/dL and <650 ng/dL. Table 1 summarizes adverse reactions (≥2%) reported in a one-year study with XYOSTED. Table 1. Number (%) of Patients with Adverse Reactions ≥2% in a 1 Year study with XYOSTED Preferred Term Overall (N=150) n (%) Hematocrit increased 21 (14.0) Hypertension 19 (12.7) Prostatic specific antigen (PSA) increased 18 (12.0) Injection site bruising 10 (6.7) Headache 8 (5.3) Back pain 5 (3.3) Blood creatine phosphokinase increased 5 (3.3) Injection site hemorrhage 5 (3.3) Acne 4…

Who shouldn’t take testosterone enanthate

XYOSTED is contraindicated in: Men with carcinoma of the breast or known or suspected carcinoma of the prostate [see Warnings and Precautions ( 5.4 )] . Women who are pregnant. Testosterone can cause virilization of the female fetus when administered to a pregnant woman [see Use in Specific Populations ( 8.1 )] . Men with known hypersensitivity to XYOSTED or any of its ingredients (testosterone enanthate and sesame oil). Men with carcinoma of the breast or known or suspected carcinoma of the prostate ( 4 , 5.4 ). Women who are pregnant ( 4 , 8.1 ). Testosterone may cause fetal harm ( 4 , 5.7 , 8.1 , and 8.2 ). Known hypersensitivity to XYOSTED or its ingredients ( 4 ).

Testosterone Enanthate drug interactions

Androgens may decrease blood glucose, and therefore may decrease insulin requirements in diabetic patients ( 7.1 ). Changes in anticoagulant activity may be seen with androgens. More frequent monitoring of international normalized ratio (INR) and prothrombin time is recommended in patients taking warfarin ( 7.2 ). Use of testosterone with corticosteroids may result in increased fluid retention. Use with caution, particularly in patients with cardiac, renal, or hepatic disease ( 7.3 ). Concomitant administration of medications that are known to increase BP with XYOSTED may lead to additional increases in BP ( 7.4 ). 7.1 Insulin Changes in insulin sensitivity or glycemic control may occur in patients treated with androgens. In diabetic patients, the metabolic effects of androgens may decrease blood glucose and, therefore, may necessitate a decrease in the dose of anti-diabetic medication. 7.2 Oral Anticoagulants Changes in anticoagulant activity may be seen with androgens, therefore more frequent monitoring of international normalized ratio (INR) and prothrombin time are recommended in patients taking warfarin, especially at the initiation and termination of androgen therapy. 7.3 Corticosteroids The concurrent use of testosterone with corticosteroids may result in increased fluid retention and requires careful monitoring, particularly in patients with cardiac, renal or hepatic disease. 7.4 Medications that May Also Increase Blood Pressure Some prescription medications and nonprescription analgesic and cold medications contain drugs known to increase blood pressure. Concomitant administration of these medications with XYOSTED may lead to additional increases in blood pressure.

Every testosterone enanthate product we track (2)

Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.

Testosterone Enanthate products
#	Drug	Rating	Type	Form	Generic?	Pharmacy pays
1	Delatestryl	72/100	Prescription	Injectable	No data	—	View →
2	Xyosted (Autoinjector)	Not yet rated	Prescription	Injectable	No data	—	View →

How long testosterone enanthate keeps

No testosterone enanthate label we read sets a separate limit for after opening, but they do specify how it must be stored — and the stability behind any date assumes those conditions.

Does testosterone enanthate expire? The in-use limits and storage rules from its labels

What people report to the FDA about testosterone enanthate

The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 564 reports naming testosterone enanthate, and the FDA flagged 77% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:

fatigue36 reports
cerebrovascular accident26 reports
myocardial infarction26 reports
atrial fibrillation25 reports
deep vein thrombosis23 reports
nausea22 reports
acute generalised exanthematous pustulosis21 reports
dizziness21 reports

Read these as a signal, not a rate. A report does not mean testosterone enanthate caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label section above.

Source: openFDA drug/event (FAERS), retrieved August 26, 2026.

How long testosterone enanthate stays in your system

The elimination half-life of testosterone enanthate is about 10 to 100 minutes. This is the half-life of the natural testosterone hormone itself. The FDA label notes "considerable variation... ranging from 10 to 100 minutes," reflecting how quickly free testosterone is cleared. Two caveats matter for "how long it stays in your system": (1) Formulation dominates. Injectable esters are slow-release depots that far outlast the hormone's own half-life — testosterone cypionate ~8 days, enanthate ~4.5 days, undecanoate weeks — and oral testosterone undecanoate (Jatenzo, Kyzatrex) is a prodrug cleaved to testosterone. The 10-100 minute figure is the hormone's intrinsic clearance, not the duration of a shot. (2) Testosterone converts to active metabolites — dihydrotestosterone (DHT) and estradiol — that circulate on their own timelines. Inactivation occurs primarily in the liver, so hepatic impairment can slow clearance; ~90% is excreted in urine as conjugates. Half-life is not the drug-test detection window: anti-doping tests use the testosterone/epitestosterone ratio and isotope analysis and can flag use for far longer than clearance of the hormone.

AndroGel (testosterone gel) FDA label, DailyMed — Clinical Pharmacology ↗

Half-life is how long the body takes to clear half a dose. It is not the same as how long a drug test can detect it, and it varies with age, kidney and liver function.

Related calculators

How long it stays in your system →

Frequently asked questions

What is testosterone enanthate?

XYOSTED (testosterone enanthate) injection contains testosterone enanthate, an ester derivative of an endogenous androgen, testosterone.

What kind of drug is testosterone enanthate?

The FDA classifies testosterone enanthate as an androgen. Androgens such as testosterone are male sex hormones that enter cells and bind the androgen receptor, switching on genes that drive male traits, muscle and bone growth, and reproductive function. Some testosterone is also converted in tissues to the more potent DHT. If you are checking whether it is safe to combine with something else, the class is what matters — two drugs from the same class usually should not be stacked.

How long does testosterone enanthate stay in your system?

The elimination half-life of testosterone enanthate is about 10 to 100 minutes — that is how long the body takes to clear half of a dose. This is the half-life of the natural testosterone hormone itself. The FDA label notes "considerable variation... ranging from 10 to 100 minutes," reflecting how quickly free testosterone is cleared. Two caveats matter for "how long it stays in your system": (1) Formulation dominates. Injectable esters are slow-release depots that far outlast the hormone's own half-life — testosterone cypionate ~8 days, enanthate ~4.5 days, undecanoate weeks — and oral testosterone undecanoate (Jatenzo, Kyzatrex) is a prodrug cleaved to testosterone. The 10-100 minute figure is the hormone's intrinsic clearance, not the duration of a shot. (2) Testosterone converts to active metabolites — dihydrotestosterone (DHT) and estradiol — that circulate on their own timelines. Inactivation occurs primarily in the liver, so hepatic impairment can slow clearance; ~90% is excreted in urine as conjugates. Half-life is not the drug-test detection window: anti-doping tests use the testosterone/epitestosterone ratio and isotope analysis and can flag use for far longer than clearance of the hormone. Half-life is not the same as how long a drug test can detect the drug, and it varies with age, kidney and liver function.

Can you take testosterone enanthate with other medicines?

It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run testosterone enanthate against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.

What brand names is testosterone enanthate sold under?

We track 2 testosterone enanthate-containing products in the U.S.: Delatestryl and Xyosted (Autoinjector). They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.

What forms does testosterone enanthate come in?

Across the brands we track, testosterone enanthate is currently marketed as injectable, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.

Is there a generic testosterone enanthate?

We do not currently list a generic-labelled testosterone enanthate product. That does not always mean none exists — it means none appears under a generic name in the FDA data we track. Ask your pharmacist.

Cite this page

APA: pharmaranks. (2026, July 24). Testosterone Enanthate: uses, dosing, side effects & brands. https://pharmaranks.com/drugs/testosterone-enanthate
MLA: “Testosterone Enanthate: uses, dosing, side effects & brands.” pharmaranks, 24 July 2026, https://pharmaranks.com/drugs/testosterone-enanthate.

We summarise public FDA and NIH sources — for a clinical claim, cite the primary source we link to as well.

Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.

Read the full FDA label for testosterone enanthate on DailyMed (NIH) ↗.