Soybean Oil: uses, dosing, side effects & brands
Soybean Oil is a lipid emulsion sold in the U.S. under 9 brand and generic names, for hypersensitivity and malnutrition. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.
Key facts
- Drug class
- Lipid Emulsion
- Treats (across its forms)
- Hypersensitivity and Malnutrition
- Available as
- Injectable · Emulsion
- Sold as
- 9 products — Liposyn III 10%, Liposyn III 20% and Liposyn III 30%, and others
- Prescription?
- Prescription only
- Generic available?
- Not in our catalog
- Boxed warning
- Boxed warning
How Intralipid 20% is dosed
From the FDA label for Intralipid 20% (application NDA018449). Other soybean oil products — different forms, different strengths — are dosed differently. Follow the label for the one you were prescribed.
For intravenous infusion into a peripheral or central vein. ( 2.1 ) Intralipid Pharmacy Bulk Package is only indicated for use in pharmacy admixture program for the preparation of three-in-one or total nutrition admixtures (TNAs). ( 2.2 ) Protect the admixed PN solution from light. ( 2.2 , 16 ) Recommended dosage depends on age, energy expenditure, clinical status, body weight, tolerance, ability to metabolize and eliminate lipids, and consideration of additional energy given to the patient. ( 2.3 ) Age Nutritional Requirements Initial Recommended Dosage Maximum Dosage Birth to 2 years of age (including preterm and term neonates) 0.5 g/kg/day 3 g/kg/day Pediatric patients 2 to <12 years of age 1 to 2 g/kg/day 2.5 g/kg/day Pediatric patients 12 to 17 years of age 1 g/kg/day 2 g/kg/day Adults 1 g/kg/day (stable) ≤1 g/kg/day (critically ill) 2.5 g/kg/day 2.1 Important Administration Instructions Intralipid is prepared and administered by a healthcare provider in the inpatient setting. Patients and caregivers may prepare and administer Intralipid for home use after appropriate training by a trained healthcare provider. Intralipid is for intravenous infusion into a central or peripheral vein. Do not exceed the recommended maximum infusion rate in Table 1 [see Dosage and Administration ( 2.3 ) and Warnings and Precautions ( 5.1 )]. Intralipid admixtures with osmolarity Greater than…
Everything below is the FDA label for Intralipid 20% (emulsion). Soybean Oil is also sold as injectable, and those are different medicines to take — follow the label for the one you were prescribed.
Intralipid 20% side effects
Adverse reactions described elsewhere in this Prescribing Information are: Clinical Decompensation with Rapid Infusion of Intravenous Lipid Emulsion in Neonates and Infants [see Warnings and Precautions ( 5.1 )] Parenteral Nutrition-Associated Liver Disease and Other Hepatobiliary Disorders [see Warnings and Precautions ( 5.2 )] Hypersensitivity Reactions [see Warnings and Precautions ( 5.3 )] Infections [see Warnings and Precautions ( 5.4 )] Fat Overload Syndrome [see Warnings and Precautions ( 5.5 )] Refeeding Syndrome [see Warnings and Precautions ( 5.6 )] Hypertriglyceridemia [see Warnings and Precautions ( 5.7 )] Aluminum Toxicity [see Warnings and Precautions ( 5.8 )] Most common adverse drug reactions (≥5%) from clinical trials in adults were nausea, vomiting, and pyrexia. Most common adverse drug reactions (≥5%) from clinical trials in pediatric patients were anemia, vomiting, increased gamma-glutamyltransferase, and cholestasis. ( 6.1 ) To report SUSPECTED ADVERSE REACTIONS, contact Fresenius Kabi USA, LLC at 1-800-551-7176 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.…
Who shouldn’t take Intralipid 20%
Known hypersensitivity to egg, soybean, peanut, or any of the active or inactive ingredients in Intralipid [see Warnings and Precautions ( 5.3 )] Severe disorders of lipid metabolism characterized by hypertriglyceridemia (serum triglyceride > 1,000 mg/dL) [see Warnings and Precautions ( 5.7 )] Known hypersensitivity to egg, soybean, or peanut, or any of the active ingredients or excipients. ( 4 , 5.3 ) Severe disorders of lipid metabolism characterized by hypertriglyceridemia (serum triglyceride > 1,000 mg/dL). ( 4 , 5.7 )
Intralipid 20% drug interactions
Soybean oil in Intralipid contains vitamin K 1 which may counteract the anticoagulant activity of vitamin K antagonists such as warfarin. In patients who receive concomitant Intralipid and warfarin, increase monitoring of laboratory parameters for anticoagulant activity. Vitamin K Antagonists (e.g., warfarin) : Anticoagulant activity may be counteracted; increase monitoring of coagulation parameters. ( 7 )
Every soybean oil product we track (9)
Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.
| # | Drug | Rating | Type | Form | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|
| 1 | 60/100 | Prescription | Injectable | No data | — | View → | |
| 2 | 60/100 | Prescription | Injectable | No data | — | View → | |
| 3 | 60/100 | Prescription | Injectable | No data | — | View → | |
| 4 | Not yet rated | Prescription | Emulsion | No data | — | View → | |
| 5 | Not yet rated | Prescription | Emulsion | No data | — | View → | |
| 6 | Not yet rated | Prescription | Emulsion | No data | — | View → | |
| 7 | Not yet rated | Prescription | Injectable | No data | — | View → | |
| 8 | Not yet rated | Prescription | Injectable | No data | — | View → | |
| 9 | Not yet rated | Prescription | Injectable | No data | — | View → |
Combination products containing soybean oil
A combination is a different drug — different dosing, different warnings. It is listed here so you can find it, not so you can substitute it.
How long soybean oil keeps
The date on a sealed pack is not the only one: some soybean oil labels start a second clock once the product is opened or mixed, as short as 24 hours.
Does soybean oil expire? The in-use limits and storage rules from its labelsWhat people report to the FDA about soybean oil
The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 1,663 reports naming soybean oil, and the FDA flagged 97% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:
- pyrexia201 reports
- chills178 reports
- nausea123 reports
- general physical health deterioration112 reports
- diarrhoea106 reports
- dyspnoea99 reports
- vomiting94 reports
- abdominal pain93 reports
Read these as a signal, not a rate. A report does not mean soybean oil caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label section above.
Source: openFDA drug/event (FAERS), retrieved July 26, 2026.
Related calculators
Frequently asked questions
What is Intralipid 20%?
Intralipid is a sterile, non-pyrogenic, white, homogenous lipid emulsion for intravenous infusion as a source of calories and essential fatty acids. The lipid content of Intralipid is 0.2 g/mL and comprises soybean oil. The phosphate content is 15 mmol/L. The total energy content, including fat, phospholipids, and glycerin is 2,000 kcal/L. Each 100 mL of Intralipid contains approximately 20 g soybean oil, 1.2 g egg yolk phospholipids, 2.25 g glycerin, water for injection, and sodium hydroxide for pH adjustment (pH 6 to 8.9). Intralipid has an osmolality of approximately 350 mOsmol/kg water (which represents an osmolarity of 260 mOsmoL/L). The soybean oil is a refined natural product consisting of a mixture of neutral triglycerides of predominantly unsaturated fatty acids with the following structure: where are saturated and unsaturated fatty acid residues. The major component fatty acids in Intralipid are linoleic acid (44% to 62%), oleic acid (19% to 30%), palmitic acid (7% to 14%), alpha-linolenic acid (4% to 11%), and stearic acid (1.4% to 5.5%). These fatty acids have the following chemical and structural formulas: Purified egg phosphatides are a mixture of naturally occurring phospholipids which are isolated from the egg yolk. These phospholipids have the following general structure: contain saturated and unsaturated fatty acids that abound in neutral fats. R 3 is…
What kind of drug is soybean oil?
The FDA classifies soybean oil as a lipid emulsion. If you are checking whether it is safe to combine with something else, the class is what matters — two drugs from the same class usually should not be stacked.
Can you take soybean oil with other medicines?
It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run soybean oil against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.
What brand names is soybean oil sold under?
We track 9 soybean oil-containing products in the U.S.: Liposyn III 10%, Liposyn III 20%, Liposyn III 30%, Intralipid 10%, Intralipid 20%, Intralipid 30%, Soyacal 10% and Soyacal 20%, and 1 more. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.
What forms does soybean oil come in?
Across the brands we track, soybean oil is currently marketed as injectable and emulsion, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.
Is there a generic soybean oil?
We do not currently list a generic-labelled soybean oil product. That does not always mean none exists — it means none appears under a generic name in the FDA data we track. Ask your pharmacist.
Cite this page
- APA
- pharmaranks. (2026, July 24). Soybean Oil: uses, dosing, side effects & brands. https://pharmaranks.com/drugs/soybean-oil
- MLA
- “Soybean Oil: uses, dosing, side effects & brands.” pharmaranks, 24 July 2026, https://pharmaranks.com/drugs/soybean-oil.
We summarise public FDA and NIH sources — for a clinical claim, cite the primary source we link to as well.
Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.
Read the full FDA label for soybean oil on DailyMed (NIH) ↗ — including its boxed warning in full.