Ramipril is a 2-aza-bicyclo [3.3.0]-octane-3-carboxylic acid derivative. It is a white, crystalline substance soluble in polar organic solvents and buffered aqueous solutions. Ramipril melts between 105°- 112°C. The CAS Registry Number is 87333-19-5. Ramipril's chemical name is (2S,3aS,6aS)-1[(S)-N-[(S)-1-Carboxy-3-phenylpropyl] alanyl] octahydrocyclopenta [b]pyrrole-2-carboxylic acid, 1-ethyl ester: The inactive ingredients are lactose monohydrate, magnesium stearate, gelatin and titanium dioxide. The 1.25 mg capsule shell contains yellow iron oxide, the 2.5 mg capsule shell contains FD&C red #3, yellow iron oxide, the 5 mg capsule shell contains FD&C blue #2, FD&C red #3, and the 10 mg capsule shell contains FD&C blue #1, FD&C red #3, black iron oxide. The structural formula for ramipril is: Its empirical formula is C 23 H 32 N 2 O 5 and its molecular weight is 416.5. Ramiprilat, the diacid metabolite of ramipril, is a non-sulfhydryl ACE inhibitor. Ramipril is converted to ramiprilat by hepatic cleavage of the ester group. chemstructure

What kind of drug is ramipril?

The FDA classifies ramipril as an angiotensin converting enzyme inhibitor. If you are checking whether it is safe to combine with something else, the class is what matters — two drugs from the same class usually should not be stacked.

Can you take ramipril with other medicines?

It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run ramipril against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.

What brand names is ramipril sold under?

We track 2 ramipril-containing products in the U.S.: Altace and Vostally. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.

What forms does ramipril come in?

Across the brands we track, ramipril is currently marketed as tablet, capsule and solution, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.

Is there a generic ramipril?

We do not currently list a generic-labelled ramipril product. That does not always mean none exists — it means none appears under a generic name in the FDA data we track. Ask your pharmacist.

Has ramipril been recalled?

The FDA's Enforcement database lists 3 recall records whose product description mentions ramipril. The most recent: Ramipril Capsules USP 5 mg (Oct 23, 2024). A recall applies to specific lots, not to the drug as a whole — check the record for the affected lot numbers.

Ramipril: uses, dosing, side effects & brands

Ramipril is an angiotensin converting enzyme inhibitor sold in the U.S. under 2 brand and generic names, for diabetic nephropathies, heart failure and hypertension. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.

By the pharmaranks editorial teamReviewed against the FDA (openFDA label, NDC Directory & Enforcement) sourcesHow we research

Key facts

Drug class: Angiotensin Converting Enzyme Inhibitor
Treats: Diabetic Nephropathies, Heart Failure and Hypertension
Available as: Tablet · Capsule · Solution
Sold as: 2 products — Altace and Vostally
Prescription?: Prescription only
Generic available?: Not in our catalog
Typical price: about $2 for a 30-count supply
Boxed warning: Boxed warning

How ramipril is dosed

From the FDA label for Altace (application NDA019901). Other ramipril products — different forms, different strengths — are dosed differently. Follow the label for the one you were prescribed.

Hypertension: Initial dose is 2.5 mg to 20 mg once daily. Adjust dosage according to blood pressure response after 2 to 4 weeks of treatment. The usual maintenance dose following titration is 2.5 mg to 20 mg daily as a single dose or equally divided doses ( 2.1 ). Reduction in the risk of myocardial infarction, stroke, or death from cardiovascular causes: 2.5 mg once daily for 1 week, 5 mg once daily for 3 weeks, and increased as tolerated to a maintenance dose of 10 mg once daily (2.2). Heart failure post-myocardial infarction: Starting dose of 2.5 mg twice daily. If patient becomes hypotensive at this dose, decrease dosage to 1.25 mg twice daily. Increase dose as tolerated toward a target dose of 5 mg twice daily, with dosage increases about 3 weeks apart (2.3). Dosage adjustment: See respective sections pertaining to dosage adjustment in special situations ( 2.5 ). 2.1 Hypertension The recommended initial dose for patients not receiving a diuretic is 2.5 mg once a day. Adjust dose according to blood pressure response. The usual maintenance dosage range is 2.5 mg to 20 mg per day administered as a single dose or in two equally divided doses. In some patients treated once daily, the antihypertensive effect may diminish toward the end of the dosing interval. In such patients, consider an increase in dosage or twice daily administration. If blood pressure is not controlled with…

Ramipril side effects

The most common adverse reactions in patients with hypertension included headache, dizziness, fatigue, and cough ( 6.1 ). To report SUSPECTED ADVERSE REACTIONS, contact CorePharma LLC. at 732-419-8800 or the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch . 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, the adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Hypertension Ramipril has been evaluated for safety in over 4000 patients with hypertension; of these, 1230 patients were studied in U.S. controlled trials, and 1107 were studied in foreign controlled trials. Almost 700 of these patients were treated for at least one year. The overall incidence of reported adverse events was similar in ramipril and placebo patients. The most frequent clinical side effects (possibly or probably related to study drug) reported by patients receiving ramipril in placebo-controlled trials were: headache (5.4%), dizziness (2.2%), and fatigue or asthenia (2.0%), but only the last one was more common in ramipril patients than in patients given placebo. Generally the side effects were mild and transient, and there was no relation to total dosage within the range of 1.25 mg - 20 mg. Discontinuation of therapy…

Ramipril and food

Potassium-rich foods & salt substitutes
Don't use potassium-based salt substitutes unless your clinician approves, and ask before taking potassium supplements. Your clinician may check your potassium level with blood tests.
Lisinopril (an ACE inhibitor) — MedlinePlus (U.S. National Library of Medicine) ↗

Every ramipril product we track (2)

Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.

Ramipril products
#	Drug	Rating	Type	Form	Generic?	Typical price
1	Altace Boxed warning	Not yet rated	Prescription	Tablet	Generic	$2	View →
2	Vostally

What ramipril pills look like

Imprint codes, colour and shape from the FDA’s labelling data. Match the imprint on your pill — or search any imprint.

Ramipril pill imprints
Imprint	Strength	Colour	Shape	Maker
LUPIN;RAMIPRIL;2;5;mg	2.5 mg	orange	capsule	—
LUPIN;RAMIPRIL;5;mg	5 mg	red	capsule	—
LUPIN;RAMIPRIL;10;mg	10 mg	blue	capsule	—
LUPIN;RAMIPRIL;1;25;mg	1.25 mg	yellow	capsule	—
ZA;44;2;5mg	2.5 mg	white, orange	capsule	—
ZA;45;5mg

Ramipril recalls

From the FDA Enforcement database. A recall covers specific lots — not the drug as a whole.

Frequently asked questions

What is ramipril?: Ramipril is a 2-aza-bicyclo [3.3.0]-octane-3-carboxylic acid derivative. It is a white, crystalline substance soluble in polar organic solvents and buffered aqueous solutions. Ramipril melts between 105°- 112°C. The CAS Registry Number is 87333-19-5. Ramipril's chemical name is (2S,3aS,6aS)-1[(S)-N-[(S)-1-Carboxy-3-phenylpropyl] alanyl] octahydrocyclopenta [b]pyrrole-2-carboxylic acid, 1-ethyl ester: The inactive ingredients are lactose monohydrate, magnesium stearate, gelatin and titanium dioxide. The 1.25 mg capsule shell contains yellow iron oxide, the 2.5 mg capsule shell contains FD&C red #3, yellow iron oxide, the 5 mg capsule shell contains FD&C blue #2, FD&C red #3, and the 10 mg capsule shell contains FD&C blue #1, FD&C red #3, black iron oxide. The structural formula for ramipril is: Its empirical formula is C 23 H 32 N 2 O 5 and its molecular weight is 416.5. Ramiprilat, the diacid metabolite of ramipril, is a non-sulfhydryl ACE inhibitor. Ramipril is converted to ramiprilat by hepatic cleavage of the ester group. chemstructure
What kind of drug is ramipril?: The FDA classifies ramipril as an angiotensin converting enzyme inhibitor. If you are checking whether it is safe to combine with something else, the class is what matters — two drugs from the same class usually should not be stacked.
Can you take ramipril with other medicines?: It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run ramipril against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.
What brand names is ramipril sold under?: We track 2 ramipril-containing products in the U.S.: Altace and Vostally. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.
What forms does ramipril come in?: Across the brands we track, ramipril is currently marketed as tablet, capsule and solution, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.

Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.