Question 1

What is progesterone?

Accepted Answer

PROMETRIUM ® (progesterone, USP) Capsules contain micronized progesterone for oral administration. Progesterone has a molecular weight of 314.47 and a molecular formula of C 21 H 30 O 2 . Progesterone (pregn-4-ene-3, 20-dione) is a white or creamy white, odorless, crystalline powder practically insoluble in water, soluble in alcohol, acetone and dioxane and sparingly soluble in vegetable oils, stable in air, melting between 126° and 131°C. The structural formula is: Progesterone is synthesized from a starting material from a plant source and is chemically identical to progesterone of human ovarian origin. PROMETRIUM Capsules are available in multiple strengths to afford dosage flexibility for optimum management. PROMETRIUM Capsules contain 100 mg or 200 mg micronized progesterone. The inactive ingredients for PROMETRIUM Capsules 100 mg include: peanut oil NF, gelatin NF, glycerin USP, lecithin NF, titanium dioxide USP, FD&C Red No. 40, and D&C Yellow No. 10. The inactive ingredients for PROMETRIUM Capsules 200 mg include: peanut oil NF, gelatin NF, glycerin USP, lecithin NF, titanium dioxide USP, D&C Yellow No. 10, and FD&C Yellow No. 6. Chemical Structure

Question 2

What kind of drug is progesterone?

Accepted Answer

The FDA classifies progesterone as a progesterone. If you are checking whether it is safe to combine with something else, the class is what matters — two drugs from the same class usually should not be stacked.

Question 3

Can you take progesterone with other medicines?

Accepted Answer

It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run progesterone against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.

Question 4

What brand names is progesterone sold under?

Accepted Answer

We track 5 progesterone-containing products in the U.S.: Crinone, Milprosa, Progestasert, Progesterone and Prometrium. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.

Question 5

What forms does progesterone come in?

Accepted Answer

Across the brands we track, progesterone is currently marketed as topical, system, insert, extended release, capsule, injectable, solution, insert and liquid, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.

Question 6

Is there a generic progesterone?

Accepted Answer

Yes. Our catalog lists 1 generic progesterone product alongside the brand versions. A generic has the same active ingredient and must meet the FDA's bioequivalence standard; it usually costs less. Ask your pharmacist which one your plan covers.

Question 7

Has progesterone been recalled?

Accepted Answer

The FDA's Enforcement database lists at least 5 recall records whose product description mentions progesterone. The most recent: Medroxyprogesterone Acetate Injectable Suspension (Apr 25, 2025). A recall applies to specific lots, not to the drug as a whole — check the record for the affected lot numbers.

#	Drug	Rating	Type	Form	Generic?	Typical price
1	Crinone	70/100	Prescription	Topical	Generic	$12	View →
2	Milprosa	70/100	Prescription	System	Generic

Imprint	Strength	Colour	Shape	Maker
555;873;b	5 mg	white	round	—
P1	100 mg	white	round	—
PREMPRO;0625;25	0.625 mg / 2.5 mg	orange	oval	—
PREMPRO;0625;25	0.625 mg / 2.5 mg	orange	oval	—
PREMPRO;03;15	0.3 mg / 1.5 mg	yellow	oval	—
PREMPRO;0625;25

Progesterone: uses, dosing, side effects & brands

Key facts

How progesterone is dosed

Progesterone side effects

Who shouldn’t take progesterone

Every progesterone product we track (5)

What progesterone pills look like

Combination products containing progesterone

Progesterone recalls

Frequently asked questions