Pregabalin is described chemically as ( S )-3-(aminomethyl)-5-methylhexanoic acid. The molecular formula is C 8 H 17 NO 2 and the molecular weight is 159.23. The chemical structure of pregabalin is: Pregabalin is a white to off-white, crystalline solid with a pK a1 of 4.2 and a pK a2 of 10.6. It is freely soluble in water and both basic and acidic aqueous solutions. The log of the partition coefficient (n-octanol/0.05M phosphate buffer) at pH 7.4 is -1.35. Pregabalin oral solution, 20 mg/mL, is administered orally and is supplied as a clear, colorless solution contained in a 16 fluid ounce white HDPE bottle with a polyethylene-lined closure. The oral solution contains 20 mg/mL of pregabalin, along with artificial strawberry #11545, dibasic sodium phosphate anhydrous, methylparaben, monobasic sodium phosphate anhydrous, propylparaben, purified water, and sucralose as inactive ingredients. Pregabalin Structural Formula

Can you take pregabalin with other medicines?

It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run pregabalin against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.

What brand names is pregabalin sold under?

We track 3 pregabalin-containing products in the U.S.: Lyrica, Lyrica CR and Pregabalin. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.

What forms does pregabalin come in?

Across the brands we track, pregabalin is currently marketed as capsule, solution and tablet, extended release, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.

Is there a generic pregabalin?

Yes. Our catalog lists 1 generic pregabalin product alongside the brand versions. A generic has the same active ingredient and must meet the FDA's bioequivalence standard; it usually costs less. Ask your pharmacist which one your plan covers.

Has pregabalin been recalled?

The FDA's Enforcement database lists 1 recall record whose product description mentions pregabalin. The most recent: Pregabalin Capsules 50mg (May 16, 2024). A recall applies to specific lots, not to the drug as a whole — check the record for the affected lot numbers.

Pregabalin: uses, dosing, side effects & brands

Pregabalin is a medicine sold in the U.S. under 3 brand and generic names, for fibromyalgia, seizures and spinal cord injuries. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.

By the pharmaranks editorial teamReviewed against the FDA (openFDA label, NDC Directory & Enforcement) sourcesHow we research

Key facts

Treats: Fibromyalgia, Seizures and Spinal Cord Injuries
Available as: Capsule · Solution · Tablet, extended release
Sold as: 3 products — Lyrica, Lyrica CR and Pregabalin
Prescription?: Prescription only
Generic available?: Yes
Half-life: about 6.3 hours (mean, in adults with normal kidney function)
Typical price: about $2 for a 30-count supply

How pregabalin is dosed

From the FDA label for Lyrica (application NDA022488). Other pregabalin products — different forms, different strengths — are dosed differently. Follow the label for the one you were prescribed.

For adult indications, begin dosing at 150 mg/day. For partial-onset seizure dosing in pediatric patients 1 month of age and older, refer to section 2.4 . ( 2.2 , 2.3 , 2.4 , 2.5 , 2.6 ) • Dosing recommendations: INDICATION Dosing Regimen Maximum Dose DPN Pain ( 2.2 ) 3 divided doses per day 300 mg/day within 1 week. PHN ( 2.3 ) 2 or 3 divided doses per day 300 mg/day within 1 week. Maximum dose of 600 mg/day. Adjunctive Therapy for Partial-Onset Seizures in Pediatric and Adult Patients Weighing 30 kg or More ( 2.4 ) 2 or 3 divided doses per day Maximum dose of 600 mg/day. Adjunctive Therapy for Partial-Onset Seizures in Pediatric Patients Weighing Less than 30 kg ( 2.4 ) 1 month to less than 4 years: 3 divided doses per day 4 years and older: 2 or 3 divided doses per day 14 mg/kg/day. Fibromyalgia ( 2.5 ) 2 divided doses per day 300 mg/day within 1 week. Maximum dose of 450 mg/day. Neuropathic Pain Associated with Spinal Cord Injury ( 2.6 ) 2 divided doses per day 300 mg/day within 1 week. Maximum dose of 600 mg/day. • Dose should be adjusted in adult patients with reduced renal function. ( 2.7 ) 2.1 Important Administration Instructions Pregabalin is given orally with or without food. When discontinuing pregabalin, taper gradually over a minimum of 1 week [see Warnings and Precautions (5.4) ] . Because pregabalin is eliminated primarily by renal…

Pregabalin side effects

The following serious adverse reactions are described elsewhere in the labeling: • Angioedema [see Warnings and Precautions (5.1) ] • Hypersensitivity [see Warnings and Precautions (5.2) ] • Suicidal Behavior and Ideation [see Warnings and Precautions (5.3) ] • Increased Risk of Adverse Reactions with Abrupt or Rapid Discontinuation [see Warnings and Precautions (5.4) ] • Respiratory Depression [see Warnings and Precautions (5.5) ] • Dizziness and Somnolence [see Warnings and Precautions (5.6) ] • Peripheral Edema [see Warnings and Precautions (5.7) ] • Weight Gain [see Warnings and Precautions (5.8) ] • Tumorigenic Potential [see Warnings and Precautions (5.9) ] • Ophthalmological Effects [see Warnings and Precautions (5.10) ] • Creatine Kinase Elevations [see Warnings and Precautions (5.11) ] • Decreased Platelet Count [see Warnings and Precautions (5.12) ] • PR Interval Prolongation [see Warnings and Precautions (5.13) ] Most common adverse reactions (greater than or equal to 5% and twice placebo) in adults are dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, and thinking abnormal (primarily difficulty with concentration/attention). ( 6.1 ) Most common adverse reactions (greater than or equal to 5% and twice placebo) in pediatric patients for the treatment of partial-onset seizures are increased weight and increased appetite. ( 6.1 ) To report SUSPECTED…

Every pregabalin product we track (3)

Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.

Pregabalin products
#	Drug	Rating	Type	Form	Generic?	Typical price
1	Lyrica	Not yet rated	Prescription	Capsule	Generic	$2	View →
2	Lyrica CR	Not yet rated	Prescription	Tablet	Generic	$2	View →

What pregabalin pills look like

Imprint codes, colour and shape from the FDA’s labelling data. Match the imprint on your pill — or search any imprint.

Pregabalin pill imprints
Imprint	Strength	Colour	Shape	Maker
PGBN;75	75 mg	white	capsule	—
142;J	150 mg	white	capsule	—
554;25mg	25 mg	white, orange	capsule	—
555;50mg	50 mg	white, orange	capsule	—
556;75mg	75 mg	orange	capsule	—
557;100mg	100 mg

Pregabalin recalls

From the FDA Enforcement database. A recall covers specific lots — not the drug as a whole.

Pregabalin Capsules 50mg
Presence of Foreign Tablets/Capsules: Complaint received from a re-packager, American Health Packaging (AHP), where a foreign tablet was discovered in one of the bottles during packaging set up. Tablet identified as pantoprazole tablet 20mg.
Rising Pharma Holding, Inc. · May 16, 2024

How long pregabalin stays in your system

The elimination half-life of pregabalin is about 6.3 hours (mean, in adults with normal kidney function). Pregabalin has no active metabolite of concern — it is excreted almost entirely unchanged in the urine and barely metabolized — but its half-life is prolonged in people with reduced kidney function, because elimination is nearly proportional to creatinine clearance.

LYRICA (pregabalin) Capsules and Oral Solution — FDA prescribing information, DailyMed ↗

Half-life is how long the body takes to clear half a dose. It is not the same as how long a drug test can detect it, and it varies with age, kidney and liver function.

Frequently asked questions

What is pregabalin?: Pregabalin is described chemically as ( S )-3-(aminomethyl)-5-methylhexanoic acid. The molecular formula is C 8 H 17 NO 2 and the molecular weight is 159.23. The chemical structure of pregabalin is: Pregabalin is a white to off-white, crystalline solid with a pK a1 of 4.2 and a pK a2 of 10.6. It is freely soluble in water and both basic and acidic aqueous solutions. The log of the partition coefficient (n-octanol/0.05M phosphate buffer) at pH 7.4 is -1.35. Pregabalin oral solution, 20 mg/mL, is administered orally and is supplied as a clear, colorless solution contained in a 16 fluid ounce white HDPE bottle with a polyethylene-lined closure. The oral solution contains 20 mg/mL of pregabalin, along with artificial strawberry #11545, dibasic sodium phosphate anhydrous, methylparaben, monobasic sodium phosphate anhydrous, propylparaben, purified water, and sucralose as inactive ingredients. Pregabalin Structural Formula
How long does pregabalin stay in your system?: The elimination half-life of pregabalin is about 6.3 hours (mean, in adults with normal kidney function) — that is how long the body takes to clear half of a dose. Pregabalin has no active metabolite of concern — it is excreted almost entirely unchanged in the urine and barely metabolized — but its half-life is prolonged in people with reduced kidney function, because elimination is nearly proportional to creatinine clearance. Half-life is not the same as how long a drug test can detect the drug, and it varies with age, kidney and liver function.
Can you take pregabalin with other medicines?: It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run pregabalin against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.
What brand names is pregabalin sold under?: We track 3 pregabalin-containing products in the U.S.: Lyrica, Lyrica CR and Pregabalin. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.

Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.