Perphenazine: uses, dosing, side effects & brands
Perphenazine is a medicine sold in the U.S. under 2 brand and generic names. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.
Key facts
- Available as
- Tablet
- Sold as
- 2 products — Perphenazine and Trilafon
- Prescription?
- Prescription only
- Generic available?
- Yes
- What the pharmacy pays
- about $6 for a 30-count supply — not your price
Every perphenazine product we track (2)
Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.
| # | Drug | Rating | Type | Form | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|
| 1 | 68/100 | Prescription | Tablet | Generic | $6 | View → | |
| 2 | Not yet rated | Prescription | Tablet | Generic | $6 | View → |
What perphenazine pills look like
Imprint codes, colour and shape from the FDA’s labelling data. Match the imprint on your pill — or search any imprint.
Combination products containing perphenazine
A combination is a different drug — different dosing, different warnings. It is listed here so you can find it, not so you can substitute it.
How long perphenazine keeps
No perphenazine label we read sets a separate limit for after opening, but they do specify how it must be stored — and the stability behind any date assumes those conditions.
Perphenazine and breastfeeding
From LactMed, the US National Library of Medicine’s Drugs and Lactation Database — quoted, not rewritten.
Full LactMed record for perphenazine: levels in milk, effects in breastfed infants, and the drugs it would consider insteadLimited information indicates that maternal doses of perphenazine up to 24 mg daily produce low levels in milk. Very limited long-term follow-up data indicate no adverse developmental effects when other phenothiazines are used alone. Monitor the infant for excessive drowsiness during breastfeeding and for developmental milestones, especially if other antipsychotics are used concurrently.
National Institute of Child Health and Human Development, record revised November 15, 2024. LactMed states its information is not a substitute for professional judgement.
What people report to the FDA about perphenazine
The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 2,669 reports naming perphenazine, and the FDA flagged 83% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:
- weight increased245 reports
- fall197 reports
- akathisia191 reports
- constipation175 reports
- hypotension174 reports
- mobility decreased172 reports
- obsessive-compulsive disorder168 reports
- increased appetite161 reports
Read these as a signal, not a rate. A report does not mean perphenazine caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label.
Source: openFDA drug/event (FAERS), retrieved September 25, 2026.
Related calculators
Frequently asked questions
Can you take perphenazine with other medicines?
It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run perphenazine against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.
What brand names is perphenazine sold under?
We track 2 perphenazine-containing products in the U.S.: Perphenazine and Trilafon. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.
What forms does perphenazine come in?
Across the brands we track, perphenazine is currently marketed as tablet, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.
Is there a generic perphenazine?
Yes. Our catalog lists 1 generic perphenazine product alongside the brand versions. A generic has the same active ingredient and must meet the FDA's bioequivalence standard; it usually costs less. Ask your pharmacist which one your plan covers.
Cite this page
- APA
- pharmaranks. (2026, July 24). Perphenazine: uses, dosing, side effects & brands. https://pharmaranks.com/drugs/perphenazine
- MLA
- “Perphenazine: uses, dosing, side effects & brands.” pharmaranks, 24 July 2026, https://pharmaranks.com/drugs/perphenazine.
We summarise public FDA and NIH sources — for a clinical claim, cite the primary source we link to as well.
Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.
Read the full FDA label for perphenazine on DailyMed (NIH) ↗.