Indocyanine Green: uses, dosing, side effects & brands
Indocyanine Green is a medicine sold in the U.S. under 3 brand and generic names. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.
Key facts
- Available as
- Kit · Powder · Solution
- Sold as
- 3 products — Ic-Green, Spy Agent Green Kit and Zyogreen
- Prescription?
- Prescription only
- Generic available?
- Not in our catalog
How Ic-Green is dosed
From the FDA label for Ic-Green (application NDA011525). Other indocyanine green products — different forms, different strengths — are dosed differently. Follow the label for the one you were prescribed.
Visualization of vessels, blood flow and tissue perfusion (2.5 mg/mL solution) o 1.25 mg to 5 mg by intravenous injection is recommended for a surgical procedure in adults and pediatric patients aged 1 month and older. o 3.75 mg to 10 mg by intravenous injection is recommended for visualization of perfusion in extremities through the skin for plastic, micro- and reconstructive surgeries in adults. o Additional doses may be administered. Do not exceed a total dose of 2 mg/kg. ( 2.1 ) • Visualization of extrahepatic biliary ducts in adults and pediatric patients aged 12 years and older (2.5 mg/mL solution) o 2.5 mg by intravenous injection at least 45 minutes prior to surgery. o Additional doses may be administered. Do not exceed a total dose of 2 mg/kg. ( 2.2 ) • Lymphatic mapping of cervical and uterine cancer in adults (1.25 mg/mL solution) o 5 mg interstitially as four 1 mL injections. o See Full Prescribing Information for injection techniques. ( 2.3 ) • Ophthalmic Angiography o Doses up to 40 mg in 2 mL of Sterile Water for Injection by intravenous injection. ( 2.4 ) • See Full Prescribing Information for reconstitution instructions. ( 2.5 ). 2.1 Recommended Dose, Administration and Imaging for Visualization of Vessels, Blood Flow and Tissue Perfusion Dosing Adults: The recommended dose of IC-GREEN for a single image sequence for visualization of vessels, blood flow and…
Everything below is the FDA label for Ic-Green (kit). Indocyanine Green is also sold as powder and solution, and those are different medicines to take — follow the label for the one you were prescribed.
Ic-Green side effects
The following clinically significant adverse reactions are described elsewhere in the labeling: • Hypersensitivity Reactions [see Warnings and Precautions ( 5.1 )] . The following adverse reactions have been identified during post-approval use of IC-GREEN. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Immune System Disorders: Anaphylaxis, urticaria The most common adverse reactions reported are anaphylaxis and urticaria. ( 6 ) To report SUSPECTED ADVERSE REACTIONS, contact Diagnostic Green LLC at 1-844-424-3784 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Who shouldn’t take Ic-Green
IC-GREEN is contraindicated in patients with a history of hypersensitivity to indocyanine green. Reactions have included anaphylaxis [see Warnings and Precautions ( 5.1 )] . Hypersensitivity to indocyanine green ( 4 )
Ic-Green drug interactions
Interference with Thyroid Radioactive Iodine Uptake Studies Because IC-GREEN contains sodium iodide, the iodine-binding capacity of thyroid tissue may be reduced for at least one week following administration. Do not perform radioactive iodine uptake studies for at least one week following administration of IC-GREEN. Interference with Thyroid Radioactive Iodine Uptake Studies: Do not perform radioactive iodine uptake studies for at least one week following the use of IC-GREEN. ( 7 )
Every indocyanine green product we track (3)
Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.
| # | Drug | Rating | Type | Form | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|
| 1 | Not yet rated | Prescription | Kit | No data | — | View → | |
| 2 | Not yet rated | Prescription | Powder | No data | — | View → | |
| 3 | Not yet rated | Prescription | Solution | No data | — | View → |
How long indocyanine green keeps
No indocyanine green label we read sets a separate limit for after opening, but they do specify how it must be stored — and the stability behind any date assumes those conditions.
Does indocyanine green expire? The in-use limits and storage rules from its labelsWhat people report to the FDA about indocyanine green
The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 134 reports naming indocyanine green, and the FDA flagged 96% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:
- urticaria11 reports
- palpitations10 reports
- dyspnoea8 reports
- haemangioma congenital8 reports
- low birth weight baby8 reports
- patent ductus arteriosus8 reports
- visual acuity reduced8 reports
- anaphylactic reaction7 reports
Read these as a signal, not a rate. A report does not mean indocyanine green caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label section above.
Source: openFDA drug/event (FAERS), retrieved August 25, 2026.
Related calculators
Frequently asked questions
What is Ic-Green?
IC-GREEN (indocyanine green for injection) is an optical imaging agent for intravenous or interstitial use. Each vial contains 10 mg or 25 mg of indocyanine green with not more than 5% sodium iodide as a sterile, lyophilized, green powder.
Can you take indocyanine green with other medicines?
It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run indocyanine green against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.
What brand names is indocyanine green sold under?
We track 3 indocyanine green-containing products in the U.S.: Ic-Green, Spy Agent Green Kit and Zyogreen. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.
What forms does indocyanine green come in?
Across the brands we track, indocyanine green is currently marketed as kit, powder and solution, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.
Is there a generic indocyanine green?
We do not currently list a generic-labelled indocyanine green product. That does not always mean none exists — it means none appears under a generic name in the FDA data we track. Ask your pharmacist.
Cite this page
- APA
- pharmaranks. (2026, July 24). Indocyanine Green: uses, dosing, side effects & brands. https://pharmaranks.com/drugs/indocyanine-green
- MLA
- “Indocyanine Green: uses, dosing, side effects & brands.” pharmaranks, 24 July 2026, https://pharmaranks.com/drugs/indocyanine-green.
We summarise public FDA and NIH sources — for a clinical claim, cite the primary source we link to as well.
Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.
Read the full FDA label for indocyanine green on DailyMed (NIH) ↗.