Hyaluronidase: uses, dosing, side effects & brands
Hyaluronidase is a medicine sold in the U.S. under 2 brand and generic names. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.
Key facts
- Available as
- Injectable
- Sold as
- 2 products — Hydase and Vitrase
- Prescription?
- Prescription only
- Generic available?
- Not in our catalog
Every hyaluronidase product we track (2)
Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.
| # | Drug | Rating | Type | Form | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|
| 1 | 58/100 | Prescription | Injectable | No data | — | View → | |
| 2 | Not yet rated | Prescription | Injectable | No data | — | View → |
Combination products containing hyaluronidase
A combination is a different drug — different dosing, different warnings. It is listed here so you can find it, not so you can substitute it.
Hyaluronidase recalls
From the FDA Enforcement database. A recall covers specific lots — not the drug as a whole.
How long hyaluronidase keeps
No hyaluronidase label we read sets a separate limit for after opening, but they do specify how it must be stored — and the stability behind any date assumes those conditions.
What people report to the FDA about hyaluronidase
The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 7,548 reports naming hyaluronidase, and the FDA flagged 91% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:
- fatigue1,182 reports
- pneumonia1,107 reports
- headache1,030 reports
- sinusitis1,014 reports
- pyrexia937 reports
- malaise871 reports
- inappropriate schedule of product administration801 reports
- infection760 reports
Read these as a signal, not a rate. A report does not mean hyaluronidase caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label.
Source: openFDA drug/event (FAERS), retrieved September 25, 2026.
Related calculators
Frequently asked questions
Can you take hyaluronidase with other medicines?
It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run hyaluronidase against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.
What brand names is hyaluronidase sold under?
We track 2 hyaluronidase-containing products in the U.S.: Hydase and Vitrase. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.
What forms does hyaluronidase come in?
Across the brands we track, hyaluronidase is currently marketed as injectable, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.
Is there a generic hyaluronidase?
We do not currently list a generic-labelled hyaluronidase product. That does not always mean none exists — it means none appears under a generic name in the FDA data we track. Ask your pharmacist.
Has hyaluronidase been recalled?
The FDA's Enforcement database lists 1 recall record whose product description mentions hyaluronidase. The most recent: Hylenex recombinant (hyaluronidase) injection (Sep 11, 2024). A recall applies to specific lots, not to the drug as a whole — check the record for the affected lot numbers.
Cite this page
- APA
- pharmaranks. (2026, July 24). Hyaluronidase: uses, dosing, side effects & brands. https://pharmaranks.com/drugs/hyaluronidase
- MLA
- “Hyaluronidase: uses, dosing, side effects & brands.” pharmaranks, 24 July 2026, https://pharmaranks.com/drugs/hyaluronidase.
We summarise public FDA and NIH sources — for a clinical claim, cite the primary source we link to as well.
Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.
Read the full FDA label for hyaluronidase on DailyMed (NIH) ↗.