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Fluphenazine: uses, dosing, side effects & brands

Fluphenazine is a medicine sold in the U.S. under 2 brand and generic names. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.

By the pharmaranks editorial teamReviewed against the FDA (openFDA label, NDC Directory & Enforcement) sourcesUpdated Jul 24, 2026How we research

Key facts

Available as
Tablet
Sold as
2 products — Permitil and Prolixin
Prescription?
Prescription only
Generic available?
Not in our catalog
What the pharmacy pays
about $11 for a 30-count supply — not your price

Every fluphenazine product we track (2)

Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.

Fluphenazine products
#DrugRatingPharmacy pays
1Not yet rated$11View →
2Not yet rated$11View →

What fluphenazine pills look like

Imprint codes, colour and shape from the FDA’s labelling data. Match the imprint on your pill — or search any imprint.

Fluphenazine pill imprints
ImprintStrengthColourShape
F1;Plain10 mgorangeround
D51 mgwhiteround
E42.5 mgyellowround
E15 mggreenround
E210 mgorangeround
FL25 mgorangetriangle
F;Plain1 mgwhiteround
F3;Plain2.5 mgyellowround
F2;Plain5 mggreenround
F1;Plain10 mgorangeround
D51 mgwhiteround

Fluphenazine recalls

From the FDA Enforcement database. A recall covers specific lots — not the drug as a whole.

How long fluphenazine keeps

No fluphenazine label we read sets a separate limit for after opening, but they do specify how it must be stored — and the stability behind any date assumes those conditions.

Fluphenazine and breastfeeding

From LactMed, the US National Library of Medicine’s Drugs and Lactation Database — quoted, not rewritten.

There is no published experience with fluphenazine during breastfeeding. Very limited long-term follow-up data indicate no adverse developmental effects when other phenothiazines are used alone. Because of the lack of published experience with fluphenazine during breastfeeding, other antipsychotic agents may be preferred, especially while nursing a newborn or preterm infant. Monitor the infant for drowsiness and developmental milestones, especially if other antipsychotics are used concurrently.

Full LactMed record for fluphenazine: levels in milk, effects in breastfed infants, and the drugs it would consider instead

National Institute of Child Health and Human Development, record revised August 15, 2023. LactMed states its information is not a substitute for professional judgement.

What people report to the FDA about fluphenazine

The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 477 reports naming fluphenazine, and the FDA flagged 86% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:

  • neuroleptic malignant syndrome47 reports
  • sedation38 reports
  • akathisia32 reports
  • weight increased32 reports
  • parkinsonism31 reports
  • delusion26 reports
  • dystonia26 reports
  • constipation25 reports

Read these as a signal, not a rate. A report does not mean fluphenazine caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label.

Source: openFDA drug/event (FAERS), retrieved August 25, 2026.

Related calculators

Frequently asked questions

Can you take fluphenazine with other medicines?

It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run fluphenazine against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.

What brand names is fluphenazine sold under?

We track 2 fluphenazine-containing products in the U.S.: Permitil and Prolixin. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.

What forms does fluphenazine come in?

Across the brands we track, fluphenazine is currently marketed as tablet, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.

Is there a generic fluphenazine?

We do not currently list a generic-labelled fluphenazine product. That does not always mean none exists — it means none appears under a generic name in the FDA data we track. Ask your pharmacist.

Has fluphenazine been recalled?

The FDA's Enforcement database lists 2 recall records whose product description mentions fluphenazine. The most recent: Fluphenazine Hydrochloride Tablets 2.5mg (Mar 13, 2025). A recall applies to specific lots, not to the drug as a whole — check the record for the affected lot numbers.

Cite this page
APA
pharmaranks. (2026, July 24). Fluphenazine: uses, dosing, side effects & brands. https://pharmaranks.com/drugs/fluphenazine
MLA
“Fluphenazine: uses, dosing, side effects & brands.” pharmaranks, 24 July 2026, https://pharmaranks.com/drugs/fluphenazine.

We summarise public FDA and NIH sources — for a clinical claim, cite the primary source we link to as well.

Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.

Read the full FDA label for fluphenazine on DailyMed (NIH) ↗.