Dasatinib — uses, dosing, side effects & the brands that sell it · pharmaranks
Dasatinib: uses, dosing, side effects & brands
Dasatinib is a kinase inhibitor sold in the U.S. under 2 brand and generic names, for lymphoid leukemia and myeloid leukemia. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.
By the pharmaranks editorial team·Reviewed against the FDA (openFDA label, NDC Directory & Enforcement) sources·How we research
Key facts
Drug class
Kinase Inhibitor
Treats
Lymphoid Leukemia and Myeloid Leukemia
Available as
Tablet
Sold as
2 products — Sprycel and Phyrago
Prescription?
Prescription only
Generic available?
Not in our catalog
Typical price
about $876 for a 30-count supply
How dasatinib is dosed
From the FDA label for Sprycel (application NDA022072). Other dasatinib products — different forms, different strengths — are dosed differently. Follow the label for the one you were prescribed.
Chronic phase CML in adults: 100 mg once daily. (2) • Accelerated phase CML, myeloid or lymphoid blast phase CML, or Ph+ ALL in adults: 140 mg once daily. (2) • Chronic phase CML and ALL in pediatrics: starting dose based on body weight. (2) • Administer orally, with or without a meal. Do not crush, cut, or chew tablets. (2) 2.1 Dosage of SPRYCEL in Adult Patients The recommended starting dosage of SPRYCEL for chronic phase CML in adults is 100 mg administered orally once daily. The recommended starting dosage of SPRYCEL for accelerated phase CML, myeloid or lymphoid blast phase CML, or Ph+ ALL in adults is 140 mg administered orally once daily. Tablets should not be crushed, cut, or chewed; they should be swallowed whole. SPRYCEL can be taken with or without a meal, either in the morning or in the evening. 2.2 Dosage of SPRYCEL in Pediatric Patients with CML or Ph+ ALL The recommended starting dosage for pediatrics is based on body weight as shown in Table 1. The recommended dose should be administered orally once daily with or without food. Recalculate the dose every 3 months based on changes in body weight, or more often if necessary. Do not crush, cut or chew tablets. Swallow tablets whole. There are additional administration considerations for pediatric patients who have difficulty swallowing tablets whole [see Use in Specific Populations…
Dasatinib side effects
The following clinically significant adverse reactions are discussed in greater detail in other sections of the labeling: • Myelosuppression [see Dosage and Administration (2.5) and Warnings and Precautions (5.1) ] . • Bleeding-related events [see Warnings and Precautions (5.2) ] . • Fluid retention [see Warnings and Precautions (5.3) ] . • Cardiovascular toxicity [see Warnings and Precautions (5.4) ] . • Pulmonary arterial hypertension [see Warnings and Precautions (5.5) ] . • QT prolongation [see Warnings and Precautions (5.6) ] . • Severe dermatologic reactions [see Warnings and Precautions (5.7) ] . • Tumor lysis syndrome [see Warnings and Precautions (5.8) ] . • Effects on growth and development in pediatric patients [see Warnings and Precautions (5.10) ] . • Hepatotoxicity [see Warnings and Precautions (5.11) ] . Most common adverse reactions (≥15%) in patients receiving SPRYCEL as single-agent therapy included myelosuppression, fluid retention events, diarrhea, headache, skin rash, hemorrhage, dyspnea, fatigue, nausea, and musculoskeletal pain. (6) Most common adverse reactions (≥30%) in pediatric patients receiving SPRYCEL in combination with chemotherapy included mucositis, febrile neutropenia, pyrexia, diarrhea, nausea, vomiting, musculoskeletal pain, abdominal pain, cough, headache, rash, fatigue, constipation, arrhythmia, hypertension, edema, infections (bacterial,…
Every dasatinib product we track (2)
Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.
Imprint codes, colour and shape from the FDA’s labelling data. Match the imprint on your pill — or search any imprint.
Dasatinib pill imprints
Imprint
Strength
Colour
Shape
Maker
5C
20 mg
white
round
—
L623
50 mg
white
oval
—
L624
70 mg
white
round
—
L625
80 mg
white
triangle
—
L626
100 mg
white
oval
—
C77
140 mg
white
Frequently asked questions
What is dasatinib?
SPRYCEL (dasatinib) is a kinase inhibitor. The chemical name for dasatinib is N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide, monohydrate. The molecular formula is C 22 H 26 ClN 7 O 2 S • H 2 O, which corresponds to a formula weight of 506.02 (monohydrate). The anhydrous free base has a molecular weight of 488.01. Dasatinib has the following chemical structure: Dasatinib is a white to off-white powder. The drug substance is insoluble in water and slightly soluble in ethanol and methanol. SPRYCEL tablets are white to off-white, biconvex, film-coated tablets containing dasatinib, with the following inactive ingredients: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, hydroxypropyl cellulose, and magnesium stearate. The tablet coating consists of hypromellose, titanium dioxide, and polyethylene glycol. dasatinib-struct.jpg
What kind of drug is dasatinib?
The FDA classifies dasatinib as a kinase inhibitor. Kinase inhibitors block protein kinases, the enzymes that relay 'grow and divide' signals inside cells. By shutting down the overactive kinase signals that a tumor depends on, they help slow or stop cancer cells from multiplying. If you are checking whether it is safe to combine with something else, the class is what matters — two drugs from the same class usually should not be stacked.
Can you take dasatinib with other medicines?
It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run dasatinib against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.
What brand names is dasatinib sold under?
We track 2 dasatinib-containing products in the U.S.: Sprycel and Phyrago. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.
What forms does dasatinib come in?
Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.
Who shouldn’t take dasatinib
None. None. (4)
Dasatinib drug interactions
Strong CYP3A4 Inhibitors: Dose reduction may be necessary. (2.3 , 7.1) • Strong CYP3A4 Inducers: Dose increase may be necessary. (2.3 , 7.1) • Antacids: Avoid simultaneous administration. (7.1) • H 2 Antagonists and Proton Pump Inhibitors: Avoid coadministration. (7.1) 7.1 Effect of Other Drugs on Dasatinib Strong CYP3A4 Inhibitors The coadministration with strong CYP3A inhibitors may increase dasatinib concentrations [see Clinical Pharmacology (12.3) ] . Increased dasatinib concentrations may increase the risk of toxicity. Avoid concomitant use of strong CYP3A4 inhibitors. If concomitant administration of a strong CYP3A4 inhibitor cannot be avoided, consider a SPRYCEL dose reduction [see Dosage and Administration (2.5) ] . Strong CYP3A4 Inducers The coadministration of SPRYCEL with strong CYP3A inducers may decrease dasatinib concentrations [see Clinical Pharmacology (12.3) ] . Decreased dasatinib concentrations may reduce efficacy. Consider alternative drugs with less enzyme induction potential. If concomitant administration of a strong CYP3A4 inducer cannot be avoided, consider a SPRYCEL dose increase. Gastric Acid Reducing Agents The coadministration of SPRYCEL with a gastric acid reducing agent may decrease the concentrations of dasatinib. Decreased dasatinib concentrations may reduce efficacy. Do not administer H 2 antagonists or proton pump…
Across the brands we track, dasatinib is currently marketed as tablet, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.
Is there a generic dasatinib?
We do not currently list a generic-labelled dasatinib product. That does not always mean none exists — it means none appears under a generic name in the FDA data we track. Ask your pharmacist.