What is cyclophosphamide?

Cyclophosphamide is an alkylating drug. It is an antineoplastic drug chemically related to the nitrogen mustards. The chemical name for cyclophosphamide is 2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate, and has the following structural formula: Cyclophosphamide has a molecular formula of C 7 H 15 Cl 2 N 2 O 2 P•H 2 O and a molecular weight of 279.1. Cyclophosphamide is soluble in water, saline, or ethanol. Cyclophosphamide for Injection, USP is a sterile white crystal or crystalline powder available as 500 mg, 1 gram, and 2 gram strength single-dose vials. 500 mg vial contains 534.5 mg cyclophosphamide monohydrate equivalent to 500 mg cyclophosphamide 1 gram vial contains 1,069 mg cyclophosphamide monohydrate equivalent to 1 gram cyclophosphamide 2 gram vial contains 2,138 mg cyclophosphamide monohydrate equivalent to 2 grams cyclophosphamide Structural Formula

Can you take cyclophosphamide with other medicines?

It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run cyclophosphamide against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.

What brand names is cyclophosphamide sold under?

We track 5 cyclophosphamide-containing products in the U.S.: Cyclophosphamide, Cytoxan, Cytoxan (Lyophilized), Frindovyx and Lyophilized Cytoxan. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.

What forms does cyclophosphamide come in?

Across the brands we track, cyclophosphamide is currently marketed as injectable, powder, capsule, solution and tablet, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.

Is there a generic cyclophosphamide?

Yes. Our catalog lists 1 generic cyclophosphamide product alongside the brand versions. A generic has the same active ingredient and must meet the FDA's bioequivalence standard; it usually costs less. Ask your pharmacist which one your plan covers.

Has cyclophosphamide been recalled?

The FDA's Enforcement database lists 3 recall records whose product description mentions cyclophosphamide. The most recent: Cyclophosphamide Injection 500 mg/5 mL (100 mg/mL) (Sep 5, 2025). A recall applies to specific lots, not to the drug as a whole — check the record for the affected lot numbers.

Cyclophosphamide: uses, dosing, side effects & brands

Cyclophosphamide is a medicine sold in the U.S. under 5 brand and generic names, for autoimmune hemolytic anemia, breast neoplasms and burkitt lymphoma. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.

By the pharmaranks editorial teamReviewed against the FDA (openFDA label, NDC Directory & Enforcement) sourcesHow we research

Key facts

Treats: Autoimmune Hemolytic Anemia, Breast Neoplasms and Burkitt Lymphoma
Available as: Injectable · Powder · Capsule · Solution · Tablet
Sold as: 5 products — Cyclophosphamide, Cytoxan and Cytoxan (Lyophilized), and others
Prescription?: Prescription only
Generic available?: Yes
Typical price: about $42 for a 30-count supply

How cyclophosphamide is dosed

From the FDA label for Cyclophosphamide (application ANDA219271). Other cyclophosphamide products — different forms, different strengths — are dosed differently. Follow the label for the one you were prescribed.

During or immediately after Cyclophosphamide for Injection administration, administer adequate amounts of fluid to reduce the risk of urinary tract toxicity ( 2.1 ). Malignant Diseases: Adult and Pediatric Patients ( 2.2 ) Intravenous: Initial course for patients with no hematologic deficiency: 40 mg per kg to 50 mg per kg in divided doses over 2 to 5 days. Other regimens include 10 mg per kg to 15 mg per kg given every 7 to 10 days or 3 mg per kg to 5 mg per kg twice weekly. Oral: 1 mg per kg per day to 5 mg per kg per day for both initial and maintenance dosing. Minimal Change Nephrotic Syndrome in Pediatric Patients ( 2.3 ) Oral: 2 mg per kg daily for 8 to 12 weeks (maximum cumulative dose 168 mg per kg). Treatment beyond 90 days increases the probability of sterility in males. ( 8.4 ) 2.1 Important Administration Instructions During or immediately after the administration of Cyclophosphamide for Injection, adequate amounts of fluid should be ingested or infused to force diuresis in order to reduce the risk of urinary tract toxicity. Therefore, Cyclophosphamide for Injection should be administered in the morning. 2.2 Recommended Dosage for Malignant Diseases Adults and Pediatric Patients Intravenous Use When used as the only oncolytic drug therapy, the recommended dosage for the initial course of Cyclophosphamide for Injection for patients with no hematologic deficiency is…

Cyclophosphamide side effects

The following adverse reactions are discussed in more detail in other sections of the labeling. Hypersensitivity [see Contraindications ( 4 )] Myelosuppression, Immunosuppression, Bone Marrow Failure, and Infections [see Warnings and Precautions ( 5.1 )] Urinary Tract and Renal Toxicity [see Warnings and Precautions ( 5.2 )] Cardiotoxicity [see Warnings and Precautions ( 5.3 )] Pulmonary Toxicity [see Warnings and Precautions ( 5.4 )] Secondary Malignancies [see Warnings and Precautions ( 5.5 )] Veno-occlusive Liver Disease [see Warnings and Precautions ( 5.6 )] Infertility [see Warnings and Precautions ( 5.8 ) and Use in Specific Populations ( 8.3 , 8.4 )] Impaired Wound Healing [see Warnings and Precautions ( 5.9 )] Hyponatremia [see Warnings and Precautions ( 5.10 )] Adverse reactions reported most often include neutropenia, febrile neutropenia, fever, alopecia, nausea, vomiting, and diarrhea. ( 6.1 ) To report SUSPECTED ADVERSE REACTIONS, contact Avenacy at 1-855-283-6229 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch . 6.1 Clinical Trials and Postmarketing Experience The following adverse reactions associated with the use of cyclophosphamide were identified in clinical studies or postmarketing reports. Because some of these reactions were reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish…

Every cyclophosphamide product we track (5)

Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.

Cyclophosphamide products
#	Drug	Rating	Type	Form	Generic?	Typical price
1	Cyclophosphamide	72/100	Prescription	Injectable	Generic	$42	View →
2	Cytoxan	Not yet rated	Prescription	Tablet	Generic	$42

What cyclophosphamide pills look like

Imprint codes, colour and shape from the FDA’s labelling data. Match the imprint on your pill — or search any imprint.

Cyclophosphamide pill imprints
Imprint	Strength	Colour	Shape	Maker
BXT;25	25 mg	white	round	—
BXT;50	50 mg	white	round	—

Cyclophosphamide recalls

From the FDA Enforcement database. A recall covers specific lots — not the drug as a whole.

Frequently asked questions

What is cyclophosphamide?: Cyclophosphamide is an alkylating drug. It is an antineoplastic drug chemically related to the nitrogen mustards. The chemical name for cyclophosphamide is 2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate, and has the following structural formula: Cyclophosphamide has a molecular formula of C 7 H 15 Cl 2 N 2 O 2 P•H 2 O and a molecular weight of 279.1. Cyclophosphamide is soluble in water, saline, or ethanol. Cyclophosphamide for Injection, USP is a sterile white crystal or crystalline powder available as 500 mg, 1 gram, and 2 gram strength single-dose vials. 500 mg vial contains 534.5 mg cyclophosphamide monohydrate equivalent to 500 mg cyclophosphamide 1 gram vial contains 1,069 mg cyclophosphamide monohydrate equivalent to 1 gram cyclophosphamide 2 gram vial contains 2,138 mg cyclophosphamide monohydrate equivalent to 2 grams cyclophosphamide Structural Formula
Can you take cyclophosphamide with other medicines?: It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run cyclophosphamide against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.
What brand names is cyclophosphamide sold under?: We track 5 cyclophosphamide-containing products in the U.S.: Cyclophosphamide, Cytoxan, Cytoxan (Lyophilized), Frindovyx and Lyophilized Cytoxan. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.
What forms does cyclophosphamide come in?: Across the brands we track, cyclophosphamide is currently marketed as injectable, powder, capsule, solution and tablet, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.
Is there a generic cyclophosphamide?: Yes. Our catalog lists 1 generic cyclophosphamide product alongside the brand versions. A generic has the same active ingredient and must meet the FDA's bioequivalence standard; it usually costs less. Ask your pharmacist which one your plan covers.

Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.