Question 1

What is bivalirudin?

Accepted Answer

Bivalirudin for injection, USP contains bivalirudin which is a specific and reversible direct thrombin inhibitor. Bivalirudin is a synthetic, 20 amino acid peptide, with the chemical name of D-phenylalanyl-L-prolyl-L-arginyl-L-prolyl-glycyl-glycyl-glycyl-glycyl-L-asparagyl-glycyl-L-aspartyl-L-phenylalanyl-L-glutamyl-L-glutamyl-L-isoleucyl-L-prolyl-L-glutamyl-L-glutamyl-L-tyrosyl-L-leucine. The active pharmaceutical ingredient is in the form of bivalirudin trifluoroacetate as a white to off-white powder. The chemical name for bivalirudin trifluoroacetate is D-phenylalanyl-L-prolyl-L-arginyl-L-prolyl-glycyl-glycyl-glycyl-glycyl-L-asparagyl-glycyl-L-aspartyl-L-phenylalanyl-L-glutamyl-L-glutamyl-L-isoleucyl-L-prolyl-L-glutamyl-L-glutamyl-L-tyrosyl-L-leucine trifluoroacetate ( Figure 1 ) . The molecular weight of bivalirudin is 2,180 daltons (anhydrous free base peptide). Figure 1: Structure formula for bivalirudin trifluoroacetate Bivalirudin for injection, USP is supplied as a sterile, white to off white lyophilized cake or powder, in single-dose vials. Each vial contains 250 mg bivalirudin, equivalent to an average of 275 mg of bivalirudin trifluoroacetate*, 125 mg mannitol, and sodium hydroxide to adjust the pH to 5 to 6 (equivalent of approximately 12.5 mg sodium). When reconstituted with Sterile Water for Injection, the product yields a clear to opalescent, colorless to…

Question 2

What kind of drug is bivalirudin?

Accepted Answer

The FDA classifies bivalirudin as an anti-coagulant. If you are checking whether it is safe to combine with something else, the class is what matters — two drugs from the same class usually should not be stacked.

Question 3

Can you take bivalirudin with other medicines?

Accepted Answer

It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run bivalirudin against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.

Question 4

What brand names is bivalirudin sold under?

Accepted Answer

We track 3 bivalirudin-containing products in the U.S.: Bivalirudin, Angiomax and Angiomax Rtu. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.

Question 5

What forms does bivalirudin come in?

Accepted Answer

Across the brands we track, bivalirudin is currently marketed as injectable, powder and solution, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.

Question 6

Is there a generic bivalirudin?

Accepted Answer

Yes. Our catalog lists 1 generic bivalirudin product alongside the brand versions. A generic has the same active ingredient and must meet the FDA's bioequivalence standard; it usually costs less. Ask your pharmacist which one your plan covers.

#	Drug	Rating	Type	Form	Generic?	Typical price
1	Bivalirudin	70/100	Prescription	Injectable	—	—	View →
2	Angiomax	64/100	Prescription	Injectable	—	—

Bivalirudin: uses, dosing, side effects & brands

Key facts

How bivalirudin is dosed

Bivalirudin side effects

Every bivalirudin product we track (3)

Frequently asked questions

Who shouldn’t take bivalirudin

Bivalirudin drug interactions