apomorphine hydrocloride (apomorphine hydrochloride injection) contains apomorphine hydrochloride, a non-ergoline dopamine agonist. Apomorphine hydrochloride is chemically designated as 6aβ-Aporphine-10,11-diol hydrochloride hemihydrate with a molecular formula of C 17 H 17 NO 2 ∙ HCl ∙ ½ H 2 O. Its structural formula and molecular weight are: Figure 1: Structural Formula and Molecular Weight of Apomorphine M.W. 312.79 Apomorphine hydrochloride appears as minute, white or grayish-white glistening crystals or as white powder that is soluble in water at 80°C. Apomorphine hydrocloride is a clear, colorless, sterile solution for subcutaneous injection and is available in 3 mL (30 mg) multi-dose cartridges. Each mL of solution contains 10 mg of apomorphine hydrochloride, USP as apomorphine hydrochloride hemihydrate (equivalent to 8.55 mg apomorphine), 1 mg of sodium metabisulfite, NF and 5 mg of benzyl alcohol, NF (preservative) in water for injection, USP. In addition, each mL of solution may contain sodium hydroxide, NF and/or hydrochloric acid, NF to adjust the pH of the solution. Figure 1

What kind of drug is apomorphine?

The FDA classifies apomorphine as a dopaminergic agonist. If you are checking whether it is safe to combine with something else, the class is what matters — two drugs from the same class usually should not be stacked.

Can you take apomorphine with other medicines?

It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run apomorphine against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.

What brand names is apomorphine sold under?

We track 3 apomorphine-containing products in the U.S.: Apokyn, Kynmobi and Onapgo. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.

What forms does apomorphine come in?

Across the brands we track, apomorphine is currently marketed as injectable and film, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.

Is there a generic apomorphine?

We do not currently list a generic-labelled apomorphine product. That does not always mean none exists — it means none appears under a generic name in the FDA data we track. Ask your pharmacist.

Apomorphine: uses, dosing, side effects & brands

Apomorphine is a dopaminergic agonist sold in the U.S. under 3 brand and generic names, for parkinson disease. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.

By the pharmaranks editorial teamReviewed against the FDA (openFDA label, NDC Directory & Enforcement) sourcesHow we research

Key facts

Drug class: Dopaminergic Agonist
Treats: Parkinson Disease
Available as: Injectable · Film
Sold as: 3 products — Apokyn, Kynmobi and Onapgo
Prescription?: Prescription only
Generic available?: Not in our catalog

How apomorphine is dosed

From the FDA label for Apokyn (application NDA021264). Other apomorphine products — different forms, different strengths — are dosed differently. Follow the label for the one you were prescribed.

For subcutaneous use only ( 2.1 ) Always express apomorphine hydrocloride dose in mL to minimize dosing errors ( 2.1 ) The starting dose of apomorphine hydrocloride is 0.2 mL (2 mg); give the first dose under medical supervision; titrate the dose to effect and tolerance; the maximum recommended dose is 0.6 mL ( 2.3 ) Treatment with a concomitant antiemetic, e.g., trimethobenzamide, is recommended, starting 3 days prior to the first dose of apomorphine hydrocloride. Treatment with trimethobenzamide should only be continued as long as necessary to control nausea and vomiting, and generally no longer than two months ( 2.2 , 5.2 , 6.1 , 17 ) Apomorphine hydrocloride doses must be separated by at least 2 hours ( 2.5 ) Renal impairment: reduce test dose, and reduce starting dose to 0.1 mL (1 mg) ( 2.4 , 8.6 , 12.3 ) 2.1 Important Administration Instructions Apomorphine hydrocloride is indicated for subcutaneous administration only [see Warnings and Precautions (5.1) ] and only by a multiple-dose APOKYN ® Pen with supplied cartridges. The APOKYN ® Pen is supplied separately by a different manufacturer. The initial dose and dose titrations should be performed by a healthcare provider. Blood pressure and pulse should be measured in the supine and standing position before and after dosing. A caregiver or patient may administer apomorphine hydrocloride if a healthcare provider determines…

Apomorphine side effects

The following serious adverse reactions are discussed in more detail in the Warnings and Precautions section of labeling: Serious Adverse Reactions After Intravenous Administration [see Warnings and Precautions (5.1) ] Nausea and Vomiting [see Warnings and Precautions (5.2) ] Falling Asleep During Activities of Daily Living and Somnolence [see Warnings and Precautions (5.3) ] Syncope/Hypotension/Orthostatic Hypotension [see Warnings and Precautions (5.4) ] Falls [see Warnings and Precautions (5.5) ] Hallucinations/Psychotic-Like Behavior [see Warnings and Precautions (5.6) ] Dyskinesias [see Warnings and Precautions (5.7) ] Impulse Control/Compulsive Behaviors [see Warnings and Precautions (5.8) ] Coronary Events [see Warnings and Precautions (5.9) ] QTc Prolongation and Potential for Proarrhythymic Effects [see Warnings and Precautions (5.10) ] Withdrawal-Emergent Hyperpyrexia and Confusion [see Warnings and Precautions (5.11) ] Hypersensitivity [see Warnings and Precautions (5.12) ] Fibrotic Complications [see Warnings and Precautions (5.13) ] Priapism [see Warnings and Precautions (5.14) ] Most common adverse reactions (incidence at least 10% greater on apomorphine hydrocloride than on placebo) were yawning, drowsiness/somnolence, dyskinesias, dizziness/postural hypotension, rhinorrhea, nausea and/or vomiting, hallucination/confusion, and edema/swelling of extremities ( 6.1…

Every apomorphine product we track (3)

Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.

Apomorphine products
#	Drug	Rating	Type	Form	Generic?	Typical price
1	Apokyn	Not yet rated	Prescription	Injectable	—	—	View →
2	Kynmobi	Not yet rated	Prescription	Film	—	—	View →
3

Frequently asked questions

What is apomorphine?: apomorphine hydrocloride (apomorphine hydrochloride injection) contains apomorphine hydrochloride, a non-ergoline dopamine agonist. Apomorphine hydrochloride is chemically designated as 6aβ-Aporphine-10,11-diol hydrochloride hemihydrate with a molecular formula of C 17 H 17 NO 2 ∙ HCl ∙ ½ H 2 O. Its structural formula and molecular weight are: Figure 1: Structural Formula and Molecular Weight of Apomorphine M.W. 312.79 Apomorphine hydrochloride appears as minute, white or grayish-white glistening crystals or as white powder that is soluble in water at 80°C. Apomorphine hydrocloride is a clear, colorless, sterile solution for subcutaneous injection and is available in 3 mL (30 mg) multi-dose cartridges. Each mL of solution contains 10 mg of apomorphine hydrochloride, USP as apomorphine hydrochloride hemihydrate (equivalent to 8.55 mg apomorphine), 1 mg of sodium metabisulfite, NF and 5 mg of benzyl alcohol, NF (preservative) in water for injection, USP. In addition, each mL of solution may contain sodium hydroxide, NF and/or hydrochloric acid, NF to adjust the pH of the solution. Figure 1
What kind of drug is apomorphine?: The FDA classifies apomorphine as a dopaminergic agonist. If you are checking whether it is safe to combine with something else, the class is what matters — two drugs from the same class usually should not be stacked.
Can you take apomorphine with other medicines?: It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run apomorphine against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.
What brand names is apomorphine sold under?: We track 3 apomorphine-containing products in the U.S.: Apokyn, Kynmobi and Onapgo. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.
What forms does apomorphine come in?: Across the brands we track, apomorphine is currently marketed as injectable and film, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.

Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.

Apomorphine drug interactions

Concomitant use of antihypertensive medications and vasodilators: increased risk for hypotension, myocardial infarction, pneumonia, falls, and injuries ( 7.2 ) Dopamine antagonists such as neuroleptics or metoclopramide, may diminish the effectiveness of apomorphine hydrocloride ( 7.4 ) 7.1 5HT 3 Antagonists Based on reports of profound hypotension and loss of consciousness when apomorphine hydrocloride was administered with ondansetron, the concomitant use of apomorphine hydrocloride with 5HT 3 antagonists including antiemetics (for example, ondansetron, granisetron, dolasetron, palonosetron) and alosetron, is contraindicated. 7.2 Antihypertensive Medications and Vasodilators In clinical studies, the following adverse events were experienced more commonly in patients receiving concomitant antihypertensive medications or vasodilators (n=94) than in patients not receiving these medications (n=456): hypotension (10% vs 4%) [see Warnings and Precautions (5.4) ] , myocardial infarction (3% vs 1%), serious pneumonia (5% vs 3%), serious falls (9% vs 3%), and bone and joint injuries (6% vs 2%). Some of the events may be related to the increased incidence of hypotension in patients receiving concomitant antihypertensive medications or vasodilators [see Warnings and Precautions (5.4 , 5.5) ] . Concomitant administration of 0.4 mg sublingual nitroglycerin with apomorphine hydrocloride…