Acetylcholine Chloride: uses, dosing, side effects & brands
Acetylcholine Chloride is a medicine sold in the U.S. under 2 brand and generic names, for compassion fatigue and headache. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.
Key facts
- Treats
- Compassion Fatigue and Headache
- Available as
- Kit
- Sold as
- 2 products — Miochol and Miochol-E
- Prescription?
- Prescription only
- Generic available?
- Not in our catalog
How acetylcholine chloride is dosed
From the FDA label for Miochol-E (application NDA020213). Other acetylcholine chloride products — different forms, different strengths — are dosed differently. Follow the label for the one you were prescribed.
Miochol ™ -E (acetylcholine chloride intraocular solution) is instilled into the anterior chamber before or after securing one or more sutures. Instillation should be gentle and parallel to the iris face and tangential to pupil border. If there are no mechanical hindrances, the pupil starts to constrict in seconds and the peripheral iris is drawn away from the angle of the anterior chamber. Any anatomical hindrance to miosis must be released to permit the desired effect of the drug. In most cases, 0.5 to 2 mL produces satisfactory miosis. Note that the syringe filter supplied with Miochol-E has a priming volume of 0.6 mL (approximately). In cataract surgery, use Miochol-E only after delivery of the lens. Aqueous solutions of acetylcholine chloride are unstable. Prepare solution immediately before use. Do not use solution that is not clear and colorless. Discard any solution that has not been used.
Acetylcholine Chloride side effects
Infrequent cases of corneal edema, corneal clouding, and corneal decompensation have been reported with the use of intraocular acetylcholine. Adverse reactions have been reported rarely, which are indicative of systemic absorption. These include bradycardia, hypotension, flushing, breathing difficulties, and sweating. To report SUSPECTED ADVERSE REACTIONS, contact Bausch & Lomb Incorporated at 1-800-553-5340 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Who shouldn’t take acetylcholine chloride
Miochol-E is contraindicated in persons with a known hypersensitivity to any component of this product.
Every acetylcholine chloride product we track (2)
Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.
| # | Drug | Rating | Type | Form | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|
| 1 | 70/100 | Prescription | Solution | No data | — | View → | |
| 2 | Not yet rated | Prescription | Kit | No data | — | View → |
How long acetylcholine chloride keeps
No acetylcholine chloride label we read sets a separate limit for after opening, but they do specify how it must be stored — and the stability behind any date assumes those conditions.
Does acetylcholine chloride expire? The in-use limits and storage rules from its labelsWhat people report to the FDA about acetylcholine chloride
The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 66 reports naming acetylcholine chloride, and the FDA flagged 88% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:
- depression29 reports
- dyspnoea28 reports
- sleep disorder28 reports
- sleep disorder due to a general medical condition28 reports
- therapeutic product effect incomplete28 reports
- anxiety27 reports
- asthma27 reports
- breast cancer27 reports
Read these as a signal, not a rate. A report does not mean acetylcholine chloride caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label section above.
Source: openFDA drug/event (FAERS), retrieved July 25, 2026.
Related calculators
Frequently asked questions
What is acetylcholine chloride?
Miochol ™ -E (acetylcholine chloride intraocular solution) is a parasympathomimetic preparation for intraocular use. It is packaged in a blister pack containing one vial and one diluent ampule. The vial contains 20 mg acetylcholine chloride and 56 mg mannitol. The accompanying ampule contains 2 mL of a modified diluent of calcium chloride dihydrate, magnesium chloride hexahydrate, potassium chloride, sodium acetate trihydrate, and sterile water for injection. The reconstituted liquid will be a sterile isotonic solution (275–330 milliosmoles/kg) containing 20 mg acetylcholine chloride (1:100 solution) and 2.8% mannitol. The pH range is 5.0–8.2. Mannitol is used in the process of lyophilizing acetylcholine chloride, and is not considered an active ingredient.
Can you take acetylcholine chloride with other medicines?
It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run acetylcholine chloride against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.
What brand names is acetylcholine chloride sold under?
We track 2 acetylcholine chloride-containing products in the U.S.: Miochol and Miochol-E. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.
What forms does acetylcholine chloride come in?
Across the brands we track, acetylcholine chloride is currently marketed as kit, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.
Is there a generic acetylcholine chloride?
We do not currently list a generic-labelled acetylcholine chloride product. That does not always mean none exists — it means none appears under a generic name in the FDA data we track. Ask your pharmacist.
Cite this page
- APA
- pharmaranks. (2026, July 24). Acetylcholine Chloride: uses, dosing, side effects & brands. https://pharmaranks.com/drugs/acetylcholine-chloride
- MLA
- “Acetylcholine Chloride: uses, dosing, side effects & brands.” pharmaranks, 24 July 2026, https://pharmaranks.com/drugs/acetylcholine-chloride.
We summarise public FDA and NIH sources — for a clinical claim, cite the primary source we link to as well.
Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.
Read the full FDA label for acetylcholine chloride on DailyMed (NIH) ↗.