Yes — Sudafed (pseudoephedrine) and ibuprofen work in different ways and are commonly taken together for cold and sinus symptoms, but you must avoid doubling up on ingredients, follow the dosing on each label, and check with a pharmacist first.
Sudafed's active ingredient, pseudoephedrine, is a nasal decongestant that works by narrowing blood vessels in the nasal passages, while ibuprofen is an NSAID that relieves pain, fever, and inflammation — they act through separate mechanisms and are routinely combined in over-the-counter cold and sinus formulas (for example, Advil Cold and Sinus), so they are not generally expected to interact dangerously with each other. The NHS does not flag a direct pseudoephedrine–ibuprofen interaction; its main warning is practical — many cough and cold remedies already contain a painkiller (aspirin, paracetamol/acetaminophen, ibuprofen, or codeine), so adding more on top risks an accidental overdose of that ingredient. Separately, pseudoephedrine can raise blood pressure, and ibuprofen and other NSAIDs can also affect blood pressure, which matters for people with heart or blood-pressure problems.
Before adding ibuprofen, read the label of any cold, flu, or sinus product you are taking — if it already lists ibuprofen, aspirin, paracetamol/acetaminophen, or codeine, do not take an extra painkiller on top (NHS). Take each product exactly as directed and do not exceed the stated dose or frequency; MedlinePlus advises taking pseudoephedrine no more often than directed and stopping it and calling your doctor if cold symptoms last more than 7 days or you have a fever. Pseudoephedrine is not suitable for everyone — tell a pharmacist or doctor first if you have high blood pressure, heart disease, diabetes, an overactive thyroid, glaucoma, an enlarged prostate, liver or kidney problems, or have taken an MAOI antidepressant in the last 2 weeks; the NHS says do not give it to children under 6. Because both pseudoephedrine and ibuprofen can affect blood pressure, anyone with hypertension or heart conditions should ask a clinician before combining them. Seek prompt medical advice for chest pain, a pounding or irregular heartbeat, severe headache, stomach pain, black or bloody stools, or signs of an allergic reaction. When in doubt, ask a pharmacist — this is general information, not a substitute for individual medical advice.
This is general reference, not medical advice, and not a guarantee of safety. Interactions depend on your doses, health conditions, and other medicines. Always confirm with your pharmacist or doctor before combining products, and follow the dosing on each label.