Yes — Tylenol (acetaminophen) and ibuprofen are different kinds of pain reliever and adults can generally take them together, but stay within each drug's dosing limits and check with your pharmacist first.
Acetaminophen (Tylenol) and ibuprofen are not the same drug and don't work the same way: ibuprofen is an NSAID (anti-inflammatory) while acetaminophen is not, so they're not duplicating one ingredient and aren't generally expected to interact dangerously when each is dosed correctly. The NHS states plainly that adults can take ibuprofen at the same time as paracetamol (acetaminophen) if needed — though it suggests trying one on its own first. The real danger isn't the combination itself but exceeding the safe dose of either drug, especially by unknowingly doubling up through combination products.
Stay within each drug's limits: acetaminophen — no more than 4,000 mg per day from ALL sources (too much can cause serious, even fatal, liver damage); ibuprofen — no more than 6 nonprescription doses in 24 hours. The biggest trap is hidden duplicates: many cold, flu, and combination pain products already contain acetaminophen and/or an NSAID, so read every label (acetaminophen may appear as APAP) and never stack two products with the same ingredient. Do NOT combine ibuprofen with another NSAID such as aspirin or naproxen — the NHS warns this raises the risk of stomach ulcers and bleeding. Watch for warning signs and stop/seek care if they appear: black or bloody stools, vomiting blood or stomach pain (GI bleeding), or chest pain, shortness of breath, or one-sided weakness/slurred speech (NSAIDs raise heart attack and stroke risk). Be cautious or ask a clinician before combining if you have stomach ulcers, kidney/liver/heart disease, asthma, a bleeding disorder, are 75 or older, are pregnant (do not take ibuprofen around or after 20 weeks), drink alcohol heavily, or take blood thinners. For children, this is different from adults — don't dose a child without a doctor's or pharmacist's advice on amounts and timing. When in doubt, ask a pharmacist.
This is general reference, not medical advice, and not a guarantee of safety. Interactions depend on your doses, health conditions, and other medicines. Always confirm with your pharmacist or doctor before combining products, and follow the dosing on each label.