Maybe, but only with a clinician's sign-off: no authoritative source clears this exact combination, and Adderall's MedlinePlus drug information tells you to disclose herbal products to your doctor and pharmacist before adding them.
They pull in roughly opposite directions. Adderall (amphetamine/dextroamphetamine) is a stimulant whose MedlinePlus label warns of serious cardiovascular effects (it lists fast, pounding, or irregular heartbeat and rare sudden death, heart attack, or stroke) and can cause difficulty sleeping, anxiety, and irritability. NCCIH, meanwhile, notes ashwagandha may cause drowsiness and may interact with medications including those for high blood pressure, thyroid hormone, immunosuppressants, sedatives, and anticonvulsants. No FDA, NHS, MedlinePlus, or NIH source documents a proven dangerous interaction between this specific pair, but none clears it as safe either — and the MedlinePlus information for Adderall explicitly names herbal products and nutritional supplements among things to review with your doctor and pharmacist before starting, and lists heart conditions and high blood pressure among what to disclose. That cardiovascular overlap, plus ashwagandha's rare but real reports of liver injury, is why this needs individual medical judgment rather than a blanket yes.
Talk to the prescriber or pharmacist who manages your Adderall before adding ashwagandha — they can check your blood pressure, heart history, thyroid status, and other medications. Be cautious or avoid it if you have heart disease, high or unstable blood pressure, a thyroid or autoimmune condition, liver problems, or are pregnant or breastfeeding; NCCIH also advises against ashwagandha before surgery. Watch for unusual drowsiness, and stop and seek care for signs of liver trouble (yellowing skin or eyes, dark urine, persistent nausea, right-upper-belly pain) or for chest pain, shortness of breath, fainting, or a fast, pounding, or irregular heartbeat. NCCIH notes ashwagandha is only studied as reasonably safe short-term (up to about 3 months), with long-term safety unknown — so do not treat it as a casual, indefinite add-on to a stimulant.
This is general reference, not medical advice, and not a guarantee of safety. Interactions depend on your doses, health conditions, and other medicines. Always confirm with your pharmacist or doctor before combining products, and follow the dosing on each label.